A review on the relationship between matrix metalloproteinases (MMPS) and their natural inhibitors (tissue inhibitors of matrix metalloproteinases [timps]) and the success of an autologous arteriovenous fistula (AVF)
Since its introduction by Brescia and Cimino in 1966, arteriovenous fistula has been regarded as the best vascular access for haemodialysis purposes. However, it’s not without any drawbacks which have cost over USD1 billion in the United States alone to rectify. Intimal hyperplasia has been shown to...
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| Main Authors: | , |
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| Format: | Article |
| Language: | en |
| Published: |
IIUM Press
2021
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/92941/7/92941_A%20review%20on%20the%20relationship%20between%20matrix.pdf http://irep.iium.edu.my/92941/ https://journals.iium.edu.my/kom/index.php/imjm/article/download/1823/1230/9258 https://doi.org/10.31436/imjm.v20i4.1823 |
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| Summary: | Since its introduction by Brescia and Cimino in 1966, arteriovenous fistula has been regarded as the best vascular access for haemodialysis purposes. However, it’s not without any drawbacks which have cost over USD1 billion in the United States alone to rectify. Intimal hyperplasia has been shown to be a major contributory factor to this development. Intimal hyperplasia is a complex molecular process resulting in the unwarranted accumulation of contractile smooth muscle cells, myofibroblasts, fibroblasts, and macrophages. There is an increasing amount of evidence suggesting that matrix metalloproteinases (MMPs) and their natural inhibitors [(tissue inhibitors of matrix metalloproteinases (TIMPs)] play a pivotal role in the development of intimal hyperplasia. Our purpose in writing this review article is to examine these shreds of evidence and to suggest what future research questions need to be answered to further strengthen and clarify this relationship |
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