In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds
The WSE is a highly polar, gummy and mucilaginous bioactive content of the Nigella sativa (L.) seeds. This study reports the anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Taylor and Francis
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/92041/1/92041_In%20vivo%20anxiolytic%20and%20in%20vitro%20anti-inflammatory%20activities.pdf http://irep.iium.edu.my/92041/ https://www.tandfonline.com/doi/abs/10.1080/14786419.2019.1667348 https://doi.org/10.1080/14786419.2019.1667348 |
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| Summary: | The WSE is a highly polar, gummy and mucilaginous bioactive
content of the Nigella sativa (L.) seeds. This study reports the
anxiolytic and anti-inflammatory effects of WSE investigated using Elevated Plus Maze (EPM) and Hole-Board Test (HBT) in adult mice and human RBCs haemolysis inhibition and protein denaturation respectively. The oral WSE treatment (100 & 200 mg/kg b.w/day) for 72 hours has exhibited slightly better anxiolytic effect (p < 0.05) through the time span (92.33 & 93.33 s) spent in the opened arms of EPM vs. diazepam (1 mg/kg b.w i.p/day; 69.33 s). In HBT, only WSE (200 mg/kg b.w/day) has shown a promising number of mean head pokes (13.27 times/min) vs. diazepam (12.87 times/min). The WSE (62.5-500 mg/mL) exposure has exhibited 40.14-72.18% protection against lysis of RBCs vs. aspirin (57.04-71.48%) whilst 62.67-67.66% inhibition of protein denaturation vs. diclofenac sodium (43.11-80.64%). The current findings suggested WSE has promising anxiolytic and anti-inflammatory activities. |
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