Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

Abstract: The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon. The primed Gel/PVA hydrogels were subjected to evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic and porosity using an acidic (pH 1.2) and...

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Main Authors:	Akhlaq, Muhammad, Azad, Abul Kalam, Ullah, Inam, Nawaz, Asif, Safdar, Muhammad, Bhattacharya, Tanima, Helal Uddin, A.B.M., Abbas, Syed Atif, Mathews, Allan, Kundu, Sukalyan Kumar, Miret, Mireia Mallandrich, Murthy, H. C. Ananda, Nagaswarupa, H. P.
Format:	Article
Language:	en
Published:	Multidisciplinary Digital Publishing Institute (MDPI) 2021
Subjects:	QD Chemistry RM300 Drugs and their action RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/91015/7/91015_Methotrexate-Loaded%20Gelatin%20and%20Polyvinyl%20Alcohol.pdf http://irep.iium.edu.my/91015/ https://www.mdpi.com/2073-4360/13/14/2300 https://doi.org/10.3390/polym13142300
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