COVID-19 in children with cancer: a review of case reports
Introduction: Immunosuppressed individuals and paediatric population are susceptible to infections. This case report depicts the presentation and severity of COVID-19 infection in a single case report of a Leukemic child on chemotherapy and compares the course of disease with previously reported ca...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Faculty of Medicine and Health Sciences
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/88209/7/88209%20COVID-19%20in%20Children%20with%20Cancer.pdf http://irep.iium.edu.my/88209/ https://medic.upm.edu.my/upload/dokumen/20210129163109Complete_IHEC_2020.pdf |
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| Summary: | Introduction: Immunosuppressed individuals and paediatric population are susceptible to infections. This case report
depicts the presentation and severity of COVID-19 infection in a single case report of a Leukemic child on chemotherapy and compares the course of disease with previously reported case reports of immunocompromised children
with COVID-19. Case presentation: We reported a 27-month-old boy, known case of B-cell Acute Lymphoblastic
Leukemia in remission, which was infected with COVID-19. Our reported case was asymptomatic and recovered
well without developing any complication related to COVID-19 infection despite being immunocompromised. A
comparison made with published case reports of immunocompromised children with COVID-19 revealed variability
in the presentations whereby most of the children were mildly affected. Other factors such as concomitant infection,
the severity of immunosuppression, presence of other co-morbidities and infection by different virus subtypes may
explain the variability in the severity of COVID-19 infection. Conclusion: Mild presentation of COVID-19 in immunocompromised children can be explained by the lack of overwhelming immune responses toward SARS-CoV-2
virus in an immunocompromised host. Clinicians, however, have to be vigilant as immunocompromised children can be severely affected by COVID-19. Further studies on the pathophysiology of COVID-19 infection in immunocompromised hosts and factors contributing to variability of presentations among patients with similar immune responses are required before a firm conclusion can be made |
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