Kamlet taft parameters: A tool to alternate the usage of hazardous solvent in pharmaceutical and chemical manufacturing/synthesis - A gateway towards green technology
In chemical synthesis, the uses of solvents are inevitable, and it has been a practice since the inception of the process. With time it gets into the notice that most of the essential solvents have a great potential to cause acute health hazards, which include health-related complications as sever...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Taylors & Francis
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/86335/1/Kamlet-Taft%207.pdf http://irep.iium.edu.my/86335/ https://www.tandfonline.com/doi/abs/10.1080/22297928.2020.1860124 |
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| Summary: | In chemical synthesis, the uses of solvents are inevitable, and it has been a practice since the
inception of the process. With time it gets into the notice that most of the essential solvents have a great
potential to cause acute health hazards, which include health-related complications as severe. There was a
continuous urge to getting some solution to overcome this problem without compromising the quality of the
synthesis process. Kamlet Taft parameter (K-T) is such a tool that can provide detailed information about the
solvent characteristics related to the synthesis process thus enabling the selection of the solvent with a lower
hazardous index compared with the high one. It has also contributed significantly to tackle environmental
hazards by replacing the hazardous dipolar solvent in synthetic chemistry. A solvent pair mixture-Hydrogen
bond donor and Hydrogen bond acceptor- is used to replace the routine hazardous solvents. This review aimed
at the systematic highlight of the K-T parameters, which will be useful for the selection of suitable solvents for
different chemical synthesis, specifically giving importance to drug synthesis. The review will provide insight
into the different applications of K-T parameters to ease the comparison of these applications. It will also guide
to estimate the solvent effects in synthesis, crystallization, and formulations of pharmaceuticals and bio�pharmaceuticals with systematic classification, analysis, and comparison of the reported work. |
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