The association of serum adipokines and vitamin D level in newly diagnosed women with breast cancer: a case-control study
This study was aimed to investigate the association of serum adipokines and vitamin D level with the risk of breast cancer. A case-control study was conducted on 78 women with newly diagnosed breast cancer and 86 healthy women, aged 21 to 59 years. Level of serum HMW adiponectin, visfatin, vitamin D...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | en |
| Published: |
2020
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/86302/1/NSM35th%20Scientific%20Conference%20Dec2020%20abstract.pdf http://irep.iium.edu.my/86302/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | This study was aimed to investigate the association of serum adipokines and vitamin D level with the risk of breast cancer. A case-control study was conducted on 78 women with newly diagnosed breast cancer and 86 healthy women, aged 21 to 59 years. Level of serum HMW adiponectin, visfatin, vitamin D and anthropometric parameters were determined. Mean serum adiponectin [2.9(1.6) vs 3.6(2.0)] and Vitamin D [14.5(7.5) vs 17.7(5.7)]
concentrations were found significantly lower in cases group as compared to controls.group. The median serum visfatin of cases group was significantly higher than controls group [2.4(3.6) vs 1.7(2.1)]. Serum HMW adiponectin and vitamin D concentrations were found to be significantly associated with reduced risk of breast cancer (OR=0.79; 95% CI: 0.60-0.99, OR=0.90; 95% CI: 0.84-0.96). The risk of developing breast was 4.56-times (95% CI: 1.54-13.51) higher in women who had serum vitamin D <20 ng/ml as compared to those who had ≥20 ng/ml of serum vitamin D. Serum visfatin was seen to increase the risk of developing breast cancer in unadjusted model with OR=1.19 (95% CI: 1.01-1.39) although the association was insignificant after adjustments. We found that lower concentration level of HMW adiponectin and vitamin D may contribute to the development of breast cancer. |
|---|