A new xanthone dimer and cytotoxicity from the stem bark of calophyllum canum
A phytochemical investigation of the stem bark of Calophyllum canum resulted in the isolation of a new xanthone dimer identified as biscaloxanthone (1), together with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The structures of these co...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | en en |
| Published: |
De Gruyter
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/83074/1/61%20New%20xanthone%20Calophyllum%20.pdf http://irep.iium.edu.my/83074/7/83074_A%20new%20xanthone%20dimer%20and%20cytotoxicity%20from_Scopus.pdf http://irep.iium.edu.my/83074/ https://www.degruyter.com/view/journals/znc/ahead-of-print/article-10.1515-znc-2020-0089/article-10.1515-znc-2020-0089.xml |
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| Summary: | A phytochemical investigation of the stem bark of
Calophyllum canum resulted in the isolation of a new
xanthone dimer identified as biscaloxanthone (1), together
with four compounds; trapezifoliaxanthone (2), trapezifolixanthone A (3), taraxerone (4) and taraxerol (5). The
structures of these compounds were determined via spectroscopic methods of IR, UV, MS and NMR (1D and 2D). The
cytotoxicity of compounds 1–3 were screened against A549,
MCF-7, C33A and 3T3L1 cell lines, wherein weak cytotoxic
activities were observed (IC50 > 50 μM). |
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