Oxoaporphine alkaloids from the barks of Platymitra siamensis Craib (Annonaceae) and their cytotoxicity against MCF-7 cancer cell line
Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated f...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en en |
| Published: |
Marmara University Press
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/71573/1/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_article.pdf http://irep.iium.edu.my/71573/2/71573_Oxoaporphine%20alkaloids%20from%20the%20barks%20_wos.pdf http://irep.iium.edu.my/71573/ http://jrespharm.com/uploads/pdf/pdf_MPJ_649.pdf |
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| Summary: | Study on the chemical constituents of the dichloromethane (DCM) crude extract of Platymitra siamensis
Craib has led to the isolation of four oxoaporphine alkaloids. The compounds were identified as liriodenine (1), Omethylmoschatoline (2), lysicamine (3) and cepharadione-A (4) which were isolated first time from this species. The
structures of the isolated compounds were elucidated based on their spectral data (1H, 13C and LCMS) and reports in
the literature. Here we observed that, only alkaloid 1 exhibited obvious cytotoxic effects against MCF-7 human breast
cancer cells line with IC50 value of 31.26 µM. This work is the first attempt on phytochemical and bioactivity study on
the genus of Platymitra. |
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