Development of porous PCL-based microcarrier
Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. However, fabrication of porous PCL microcarrier was an obstacle and study of its biodegradability is also limited. In the present study, PCL-based porous microcarrier was fabricated with different parameters by us...
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| Format: | Proceeding Paper |
| Language: | en |
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International Institute for Halal research and Training (INHART), IIUM
2018
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| Online Access: | http://irep.iium.edu.my/65249/1/65249_Development%20of%20Porous%20PCL-based.pdf http://irep.iium.edu.my/65249/ http://halalinst.psu.ac.th/i-chips/ |
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| author | Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N. |
| author_facet | Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N. |
| author_sort | Mohd. Salleh, Hamzah |
| building | IIUM Library |
| collection | Institutional Repository |
| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. However, fabrication of porous PCL microcarrier was an obstacle and study of its biodegradability is also limited. In the present study, PCL-based porous microcarrier was fabricated with different parameters by using emulsion evaporation method. From the study, at 20% camphene concentration, optimum pore size was generated which was at 11.738 μm. During the fabrication of the microcarrier, most of the parameters showed effect on the size of the microcarrier. Under the biodegradability test, it showed that the porous structure of the microcarrier enhance the degradation rate of the microcarrier. Throughout the study, all the parameters tested for the fabrication of microcarrier showed effect on it and the porous structure improve the degradation rate of PCL microcarrier. |
| format | Proceeding Paper |
| id | my.iium.irep-65249 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en |
| publishDate | 2018 |
| publisher | International Institute for Halal research and Training (INHART), IIUM |
| record_format | dspace |
| spelling | my.iium.irep-652492019-01-04T07:46:11Z http://irep.iium.edu.my/65249/ Development of porous PCL-based microcarrier Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N. TP248.13 Biotechnology Polycaprolactone (PCL) has been used for cell cultivation due to its biocompatibility. However, fabrication of porous PCL microcarrier was an obstacle and study of its biodegradability is also limited. In the present study, PCL-based porous microcarrier was fabricated with different parameters by using emulsion evaporation method. From the study, at 20% camphene concentration, optimum pore size was generated which was at 11.738 μm. During the fabrication of the microcarrier, most of the parameters showed effect on the size of the microcarrier. Under the biodegradability test, it showed that the porous structure of the microcarrier enhance the degradation rate of the microcarrier. Throughout the study, all the parameters tested for the fabrication of microcarrier showed effect on it and the porous structure improve the degradation rate of PCL microcarrier. International Institute for Halal research and Training (INHART), IIUM 2018 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/65249/1/65249_Development%20of%20Porous%20PCL-based.pdf Mohd. Salleh, Hamzah and Hashim, Yumi Zuhanis Has-Yun and Samsudin, Nurhusna and Abdul Halim, Muhammad A. N. (2018) Development of porous PCL-based microcarrier. In: International Conference on Halal Innovation in Products and Services 2018 (i-CHIPS 2018), 13th-14th July 2018, Haat Yai, Songkhla, Thailand. http://halalinst.psu.ac.th/i-chips/ |
| spellingShingle | TP248.13 Biotechnology Mohd. Salleh, Hamzah Hashim, Yumi Zuhanis Has-Yun Samsudin, Nurhusna Abdul Halim, Muhammad A. N. Development of porous PCL-based microcarrier |
| title | Development of porous PCL-based microcarrier |
| title_full | Development of porous PCL-based microcarrier |
| title_fullStr | Development of porous PCL-based microcarrier |
| title_full_unstemmed | Development of porous PCL-based microcarrier |
| title_short | Development of porous PCL-based microcarrier |
| title_sort | development of porous pcl-based microcarrier |
| topic | TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/65249/1/65249_Development%20of%20Porous%20PCL-based.pdf http://irep.iium.edu.my/65249/ http://halalinst.psu.ac.th/i-chips/ |
| url_provider | http://irep.iium.edu.my/ |