Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging
Composition of atherosclerotic arterial walls is rich in lipids such as cholesterol; unlike normal arterial walls. In this study, we aimed to utilize this difference to diagnose atherosclerosis via multispectral imaging, which allows for identification of fluorescence originating from the substance...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Proceeding Paper |
| Language: | en en |
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2015
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| Online Access: | http://irep.iium.edu.my/44921/1/Development_of_Diagnostic_System.pdf http://irep.iium.edu.my/44921/4/ascc_proceeeding_cove%2C_copyright%2C_content.pdf http://irep.iium.edu.my/44921/ http://dx.doi.org/10.1109/ASCC.2015.7244623 |
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| author | Ho, C. Horiuchi, T. Taniguchi, H. Umetsu, A. Hagisawa, K. Iwaya, K. Azmi, A. Zulaziz, N. Azhim, Azran Shinomiya, N. Morimoto, Y. |
| author_facet | Ho, C. Horiuchi, T. Taniguchi, H. Umetsu, A. Hagisawa, K. Iwaya, K. Azmi, A. Zulaziz, N. Azhim, Azran Shinomiya, N. Morimoto, Y. |
| author_sort | Ho, C. |
| building | IIUM Library |
| collection | Institutional Repository |
| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | Composition of atherosclerotic arterial walls is rich in lipids such as cholesterol; unlike normal arterial walls. In this study, we aimed to utilize this difference to diagnose atherosclerosis via multispectral imaging, which allows for identification of fluorescence originating from the substance in the arterial wall. The inner surface of extracted arteries (rabbit abdominal aorta, human coronary aorta) was illuminated by an excitation light and multispectral fluorescence images were obtained. The fluorescence spectra in atherosclerotic sites were shown to be different from those in normal sites. A ratio of fluorescence intensity at a wavelength of two significant differences was then calculated for each pixel and ratio images were reconstructed. As a result, we succeeded in “disease mapping”, by which atherosclerotic sites can be discriminated from normal sites. The differences in fluorescence spectra may be attributed to the differences in fluorophores contained in the intima/media of the artery. |
| format | Proceeding Paper |
| id | my.iium.irep-44921 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en en |
| publishDate | 2015 |
| record_format | dspace |
| spelling | my.iium.irep-449212016-05-24T03:54:35Z http://irep.iium.edu.my/44921/ Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging Ho, C. Horiuchi, T. Taniguchi, H. Umetsu, A. Hagisawa, K. Iwaya, K. Azmi, A. Zulaziz, N. Azhim, Azran Shinomiya, N. Morimoto, Y. TP248.13 Biotechnology Composition of atherosclerotic arterial walls is rich in lipids such as cholesterol; unlike normal arterial walls. In this study, we aimed to utilize this difference to diagnose atherosclerosis via multispectral imaging, which allows for identification of fluorescence originating from the substance in the arterial wall. The inner surface of extracted arteries (rabbit abdominal aorta, human coronary aorta) was illuminated by an excitation light and multispectral fluorescence images were obtained. The fluorescence spectra in atherosclerotic sites were shown to be different from those in normal sites. A ratio of fluorescence intensity at a wavelength of two significant differences was then calculated for each pixel and ratio images were reconstructed. As a result, we succeeded in “disease mapping”, by which atherosclerotic sites can be discriminated from normal sites. The differences in fluorescence spectra may be attributed to the differences in fluorophores contained in the intima/media of the artery. 2015 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/44921/1/Development_of_Diagnostic_System.pdf application/pdf en http://irep.iium.edu.my/44921/4/ascc_proceeeding_cove%2C_copyright%2C_content.pdf Ho, C. and Horiuchi, T. and Taniguchi, H. and Umetsu, A. and Hagisawa, K. and Iwaya, K. and Azmi, A. and Zulaziz, N. and Azhim, Azran and Shinomiya, N. and Morimoto, Y. (2015) Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging. In: The 10th Asian Control Conference (ASCC 2015), 31 May - 3 June 2015, Kota Kinabalu, Sabah. http://dx.doi.org/10.1109/ASCC.2015.7244623 10.1109/ASCC.2015.7244623 |
| spellingShingle | TP248.13 Biotechnology Ho, C. Horiuchi, T. Taniguchi, H. Umetsu, A. Hagisawa, K. Iwaya, K. Azmi, A. Zulaziz, N. Azhim, Azran Shinomiya, N. Morimoto, Y. Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging |
| title | Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging |
| title_full | Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging |
| title_fullStr | Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging |
| title_full_unstemmed | Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging |
| title_short | Development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging |
| title_sort | development of diagnostic system for atherosclerosis based on intrinsic fluorescence using multispectral imaging |
| topic | TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/44921/1/Development_of_Diagnostic_System.pdf http://irep.iium.edu.my/44921/4/ascc_proceeeding_cove%2C_copyright%2C_content.pdf http://irep.iium.edu.my/44921/ http://dx.doi.org/10.1109/ASCC.2015.7244623 |
| url_provider | http://irep.iium.edu.my/ |