Meropenem and piperacillin/tazobactam optimised dosing regimens for critically ill patients receiving renal replacement therapy

Purpose: Optimal dosing of meropenem and piperacillin/tazobactam in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to variable pharmacokinetics. We aimed to develop generalisable optimised dosing recommendations for these antibiotics. Methods: Prospective, mult...

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Main Authors:	Roberts, Jason A., Ulldemolins, Marta, Liu, Xin, Baptista, João P., Bilgrami, Irma, Boidin, Clement, Brinkmann, Alexander, Castro, Pedro, Choi, Gordon, Cole, Louise, Waele, Jan J. De, Deans, Renae, Donnellan, Sine, Eastwood, Glenn M., Frey, Otto R., Goutelle, Sylvain, Gresham, Rebecca, Jamal, Janattul AIn, Joynt, Gavin M., Kanji, Salmaan, Kluge, Stefan, König, Christina, Koulouras, Vasilios P, Lassig-Smith, Melissa, Laterre, Pierre-Francois, Lee, Anna, Lefran, Jean‑Yves, Lei, Katie, Leung, Patricia, Llauradó-Serra, Mireia, Martin-Loeches, Ignacio, Mat Nor, Mohd Basri, Shee, Yugang, Ostermann, Marlies, Paul, Sanjoy K, Peake, Sandra L, Rello, Jordi, Roberts, Darren M., Roberts, Michael S., Doberstein, Brent, Rodríguez, Alejandro, Roehr, Anka C., Roger, Claire, Seoane, Leonardo, Sinnollareddy, Mahipal, Sousa, Eduardo, Soy, Dolors, Spring, Anna, Starr, Therese, Stephens, Dianne, Taccone, Fabio Silvio, Thomas, Jane, Turnidge, John, Valkonen, Miia, Varghese, Julie M., Wallis, Steven C, Walker, Robert J., Williams, Tricia, Wilson, Luke C., Wittebole, Xavier, Wright, Daniel F., Zikou, Xanthi T, Bellomo,, Rinaldo, Lipman, Jeffrey
Format:	Article
Language:	en en
Published:	Springer Nature 2025
Subjects:	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Online Access:	http://irep.iium.edu.my/127009/1/intensive%20care%20medicine%20Aug%202025_Prof%20Basri.pdf http://irep.iium.edu.my/127009/7/Scopus%20-%20Document%20Details.pdf http://irep.iium.edu.my/127009/ https://link.springer.com/article/10.1007/s00134-025-08067-w
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