Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence
The genus Premna (Lamiaceae), widely distributed across tropical and subtropical regions, is renowned for its ethnomedicinal applications, including cardiotonic, antimicrobial, hepatoprotective, and antitumor properties. Despite these promising uses, the current body of literature relies predominant...
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Dove Medical Press Ltd
2025
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| author | Febriyanti, Raden Maya Rafif, Syauqi Nawwar Mikdar, Nazwa Nuraizza Hikmatiana, Billa Nidia Maisyarah, Intan Timur Khatib, Alfi Muhaimin, Muhaimin |
| author_facet | Febriyanti, Raden Maya Rafif, Syauqi Nawwar Mikdar, Nazwa Nuraizza Hikmatiana, Billa Nidia Maisyarah, Intan Timur Khatib, Alfi Muhaimin, Muhaimin |
| author_sort | Febriyanti, Raden Maya |
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| continent | Asia |
| country | Malaysia |
| description | The genus Premna (Lamiaceae), widely distributed across tropical and subtropical regions, is renowned for its ethnomedicinal applications, including cardiotonic, antimicrobial, hepatoprotective, and antitumor properties. Despite these promising uses, the current body of literature relies predominantly on in vitro evidence, with limited knowledge regarding in vivo validation, metabolism, and bioavailability. This review synthesizes findings from the past decade on the Premna serratifolia group (P. serratifolia, P. odorata, and P. tomentosa), focusing on their bioactive compounds and mechanisms of in vitro anticancer activity. The compounds identified—such as flavonoids, terpenoids, and steroids—exhibit diverse actions, including cell cycle arrest, apoptosis induction, inhibition of metastasis, oxidative stress modulation, and autophagy. Key compounds like quercetin, kaempferol, and stigmasterol demonstrate multi-targeted actions, effectively regulating pathways such as PI3K/AKT and NF-κB while selectively targeting cancer cells. These findings underscore chemopreventive potential from P. serratifolia group and their ability to complement conventional cancer therapies, potentially reducing side effects and overcoming drug resistance. Furthermore, the review validates the ethnomedicinal use of Premna species and bridges traditional knowledge with modern oncology. However, the absence of comprehensive in vivo and clinical data warrants further research to fully harness these compounds’ potential. This study highlights P. serratifolia, P. odorata, and P. tomentosa as promising sources for novel plant-derived anticancer agents, offering opportunities for future drug discovery |
| format | Article |
| id | my.iium.irep-123790 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en en en |
| publishDate | 2025 |
| publisher | Dove Medical Press Ltd |
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| spelling | my.iium.irep-1237902025-10-17T09:12:36Z http://irep.iium.edu.my/123790/ Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence Febriyanti, Raden Maya Rafif, Syauqi Nawwar Mikdar, Nazwa Nuraizza Hikmatiana, Billa Nidia Maisyarah, Intan Timur Khatib, Alfi Muhaimin, Muhaimin RS403 Materia Medica-Pharmaceutical Chemistry The genus Premna (Lamiaceae), widely distributed across tropical and subtropical regions, is renowned for its ethnomedicinal applications, including cardiotonic, antimicrobial, hepatoprotective, and antitumor properties. Despite these promising uses, the current body of literature relies predominantly on in vitro evidence, with limited knowledge regarding in vivo validation, metabolism, and bioavailability. This review synthesizes findings from the past decade on the Premna serratifolia group (P. serratifolia, P. odorata, and P. tomentosa), focusing on their bioactive compounds and mechanisms of in vitro anticancer activity. The compounds identified—such as flavonoids, terpenoids, and steroids—exhibit diverse actions, including cell cycle arrest, apoptosis induction, inhibition of metastasis, oxidative stress modulation, and autophagy. Key compounds like quercetin, kaempferol, and stigmasterol demonstrate multi-targeted actions, effectively regulating pathways such as PI3K/AKT and NF-κB while selectively targeting cancer cells. These findings underscore chemopreventive potential from P. serratifolia group and their ability to complement conventional cancer therapies, potentially reducing side effects and overcoming drug resistance. Furthermore, the review validates the ethnomedicinal use of Premna species and bridges traditional knowledge with modern oncology. However, the absence of comprehensive in vivo and clinical data warrants further research to fully harness these compounds’ potential. This study highlights P. serratifolia, P. odorata, and P. tomentosa as promising sources for novel plant-derived anticancer agents, offering opportunities for future drug discovery Dove Medical Press Ltd 2025-05-26 Article PeerReviewed application/pdf en http://irep.iium.edu.my/123790/7/123790_Anticancer%20potential%20of%20bioactive%20compounds.pdf application/pdf en http://irep.iium.edu.my/123790/8/123790_Anticancer%20potential%20of%20bioactive%20compounds_WOS.pdf application/pdf en http://irep.iium.edu.my/123790/9/123790_Anticancer%20potential%20of%20bioactive%20compounds_Scopus.pdf Febriyanti, Raden Maya and Rafif, Syauqi Nawwar and Mikdar, Nazwa Nuraizza and Hikmatiana, Billa Nidia and Maisyarah, Intan Timur and Khatib, Alfi and Muhaimin, Muhaimin (2025) Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence. Cancer Management and Research, 17. pp. 1029-1045. ISSN 1179-1322 https://www.tandfonline.com/doi/full/10.2147/CMAR.S516204 10.2147/CMAR.S516204 |
| spellingShingle | RS403 Materia Medica-Pharmaceutical Chemistry Febriyanti, Raden Maya Rafif, Syauqi Nawwar Mikdar, Nazwa Nuraizza Hikmatiana, Billa Nidia Maisyarah, Intan Timur Khatib, Alfi Muhaimin, Muhaimin Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence |
| title | Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence |
| title_full | Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence |
| title_fullStr | Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence |
| title_full_unstemmed | Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence |
| title_short | Anticancer potential of bioactive compounds in Premna serratifolia, Premna odorata, and Premna tomentosa: a review of in vitro evidence |
| title_sort | anticancer potential of bioactive compounds in premna serratifolia, premna odorata, and premna tomentosa: a review of in vitro evidence |
| topic | RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/123790/7/123790_Anticancer%20potential%20of%20bioactive%20compounds.pdf http://irep.iium.edu.my/123790/8/123790_Anticancer%20potential%20of%20bioactive%20compounds_WOS.pdf http://irep.iium.edu.my/123790/9/123790_Anticancer%20potential%20of%20bioactive%20compounds_Scopus.pdf http://irep.iium.edu.my/123790/ https://www.tandfonline.com/doi/full/10.2147/CMAR.S516204 |
| url_provider | http://irep.iium.edu.my/ |