Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking
Introduction: Antimalarial drug resistance, such as artemisinin partial resistance, has become a major concern in malaria eradication. Thus, the development of new alternatives for malaria treatment is needed. Medicinal plants used by people in endemic areas, such as Physalis angulata, need to be st...
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Elsevier
2025
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| Online Access: | http://irep.iium.edu.my/123789/7/123789_Multi-target%20mechanism.pdf http://irep.iium.edu.my/123789/ https://www.sciencedirect.com/journal/journal-of-herbal-medicine |
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| author | Indradi, Raden Bayu Muhaimin, Muhaimin Barliana, Melisa Intan Khatib, Alfi Maisyarah, Intan Timur Pitaloka, Dian Ayu Eka Pratomo, Muhammad Fadhil |
| author_facet | Indradi, Raden Bayu Muhaimin, Muhaimin Barliana, Melisa Intan Khatib, Alfi Maisyarah, Intan Timur Pitaloka, Dian Ayu Eka Pratomo, Muhammad Fadhil |
| author_sort | Indradi, Raden Bayu |
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| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | Introduction: Antimalarial drug resistance, such as artemisinin partial resistance, has become a major concern in malaria eradication. Thus, the development of new alternatives for malaria treatment is needed. Medicinal plants used by people in endemic areas, such as Physalis angulata, need to be studied for their claimed efficacy to treat malaria. Methods: In this study, we used a network pharmacology approach utilising several databases (KNApSAck, GeneCards, SwissADME, Pharmmapper, SwissTargetPrediction, SuperPred, STRING-DB, DAVID) to predict the multi-mechanism of P. angulata to alleviate malaria, as confirmed by molecular docking. Results: The result revealed that 25 compounds of P. angulata interact with 22 malaria-related targets, where molecular docking performed for compounds and targets associated with malaria pathways verified that with angulatin F showed a good binding affinity with ICAM1, VCAM1, and SELE, physagulin A with IL1B, physagulin J with TNF, and physalin V with TLR4. Conclusion: We predict that P. angulata alleviates malaria through several mechanisms, primarily by regulating the inflammatory response. This mechanism reduces excess proinflammatory cytokines like TNF and IL1B, leads to reduced levels of adhesion molecules, and ultimately reduces or prevents the severity of malaria. |
| format | Article |
| id | my.iium.irep-123789 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en |
| publishDate | 2025 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | my.iium.irep-1237892025-10-21T03:54:20Z http://irep.iium.edu.my/123789/ Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking Indradi, Raden Bayu Muhaimin, Muhaimin Barliana, Melisa Intan Khatib, Alfi Maisyarah, Intan Timur Pitaloka, Dian Ayu Eka Pratomo, Muhammad Fadhil RS403 Materia Medica-Pharmaceutical Chemistry Introduction: Antimalarial drug resistance, such as artemisinin partial resistance, has become a major concern in malaria eradication. Thus, the development of new alternatives for malaria treatment is needed. Medicinal plants used by people in endemic areas, such as Physalis angulata, need to be studied for their claimed efficacy to treat malaria. Methods: In this study, we used a network pharmacology approach utilising several databases (KNApSAck, GeneCards, SwissADME, Pharmmapper, SwissTargetPrediction, SuperPred, STRING-DB, DAVID) to predict the multi-mechanism of P. angulata to alleviate malaria, as confirmed by molecular docking. Results: The result revealed that 25 compounds of P. angulata interact with 22 malaria-related targets, where molecular docking performed for compounds and targets associated with malaria pathways verified that with angulatin F showed a good binding affinity with ICAM1, VCAM1, and SELE, physagulin A with IL1B, physagulin J with TNF, and physalin V with TLR4. Conclusion: We predict that P. angulata alleviates malaria through several mechanisms, primarily by regulating the inflammatory response. This mechanism reduces excess proinflammatory cytokines like TNF and IL1B, leads to reduced levels of adhesion molecules, and ultimately reduces or prevents the severity of malaria. Elsevier 2025-04-29 Article PeerReviewed application/pdf en http://irep.iium.edu.my/123789/7/123789_Multi-target%20mechanism.pdf Indradi, Raden Bayu and Muhaimin, Muhaimin and Barliana, Melisa Intan and Khatib, Alfi and Maisyarah, Intan Timur and Pitaloka, Dian Ayu Eka and Pratomo, Muhammad Fadhil (2025) Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking. Journal of Herbal Medicine, 51. ISSN 2210-8033 E-ISSN 2210-8041 https://www.sciencedirect.com/journal/journal-of-herbal-medicine 10.1016/j.hermed.2025.101021 |
| spellingShingle | RS403 Materia Medica-Pharmaceutical Chemistry Indradi, Raden Bayu Muhaimin, Muhaimin Barliana, Melisa Intan Khatib, Alfi Maisyarah, Intan Timur Pitaloka, Dian Ayu Eka Pratomo, Muhammad Fadhil Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking |
| title | Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking |
| title_full | Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking |
| title_fullStr | Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking |
| title_full_unstemmed | Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking |
| title_short | Multi-target mechanism of Physalis angulata to treat malaria based on network pharmacology and molecular docking |
| title_sort | multi-target mechanism of physalis angulata to treat malaria based on network pharmacology and molecular docking |
| topic | RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/123789/7/123789_Multi-target%20mechanism.pdf http://irep.iium.edu.my/123789/ https://www.sciencedirect.com/journal/journal-of-herbal-medicine |
| url_provider | http://irep.iium.edu.my/ |