Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives
Cancer continues to pose a significant global health challenge, demanding innovative therapeutic approaches to overcome the limitations of conventional treatments like chemotherapy and radiotherapy. Nanoparticles (NPs) have emerged as promising tools for cancer therapy due to their unique physicoche...
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| Format: | Article |
| Language: | en en en |
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Bentham Science Publishers
2025
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| Online Access: | http://irep.iium.edu.my/123745/1/123745_Nanoparticles%20as%20novel%20drug%20delivery.pdf http://irep.iium.edu.my/123745/2/123745_Nanoparticles%20as%20novel%20drug%20delivery_SCOPUS.pdf http://irep.iium.edu.my/123745/3/123745_Nanoparticles%20as%20novel%20drug%20delivery_WOS.pdf http://irep.iium.edu.my/123745/ https://www.eurekaselect.com/article/147710 |
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| author | Liew, Kai Bin Phang, Hiu Ching Tan, Vinie Ying Xuan Kee, Phei Er Ming, Long Chiau Vijayaraj Kumar, Palanirajan Lee, Siew-Keah Helal Uddin, A.B.M. Gilhotra, Ritu M. Ramanunny, Arya Kadukkattil |
| author_facet | Liew, Kai Bin Phang, Hiu Ching Tan, Vinie Ying Xuan Kee, Phei Er Ming, Long Chiau Vijayaraj Kumar, Palanirajan Lee, Siew-Keah Helal Uddin, A.B.M. Gilhotra, Ritu M. Ramanunny, Arya Kadukkattil |
| author_sort | Liew, Kai Bin |
| building | IIUM Library |
| collection | Institutional Repository |
| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | Cancer continues to pose a significant global health challenge, demanding innovative therapeutic approaches to overcome the limitations of conventional treatments like chemotherapy and radiotherapy. Nanoparticles (NPs) have emerged as promising tools for cancer therapy due to their unique physicochemical properties that enable targeted drug delivery, reduced systemic toxicity, and enhanced therapeutic efficacy. This comprehensive review delves into the mechanisms of NP-based drug delivery, highlighting both passive and active targeting strategies. It categorizes and discusses diverse NP types, including polymeric, lipid-based, and metallic nanoparticles, emphasizing their applications in enhancing the bioavailability and specificity of anticancer
agents. This review also explores the integration of advanced technologies, such as theranostics and artificial
intelligence, to optimize NP design and functionality for personalized medicine. However, challenges remain,
including issues related to toxicity, drug resistance, and manufacturing scalability. Addressing these barriers re-
quires interdisciplinary research focused on developing stimuli-responsive NPs, improving biocompatibility,
and incorporating multimodal therapeutic platforms. Although substantial progress has been made, this review
is limited by the paucity of clinical trials validating NP efficacy and safety in diverse patient populations. Fu-
ture endeavors should prioritize translational research to bridge the gap between preclinical innovations and
clinical applications, ensuring that these transformative technologies benefit a broader spectrum of cancer pa-
tients. The review underscores the immense potential of NPs in redefining cancer treatment while advocating
for sustained research to address existing limitations and unlock their full therapeutic promise. |
| format | Article |
| id | my.iium.irep-123745 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en en en |
| publishDate | 2025 |
| publisher | Bentham Science Publishers |
| record_format | dspace |
| spelling | my.iium.irep-1237452025-11-04T03:21:02Z http://irep.iium.edu.my/123745/ Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives Liew, Kai Bin Phang, Hiu Ching Tan, Vinie Ying Xuan Kee, Phei Er Ming, Long Chiau Vijayaraj Kumar, Palanirajan Lee, Siew-Keah Helal Uddin, A.B.M. Gilhotra, Ritu M. Ramanunny, Arya Kadukkattil QD Chemistry RM Therapeutics. Pharmacology RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Cancer continues to pose a significant global health challenge, demanding innovative therapeutic approaches to overcome the limitations of conventional treatments like chemotherapy and radiotherapy. Nanoparticles (NPs) have emerged as promising tools for cancer therapy due to their unique physicochemical properties that enable targeted drug delivery, reduced systemic toxicity, and enhanced therapeutic efficacy. This comprehensive review delves into the mechanisms of NP-based drug delivery, highlighting both passive and active targeting strategies. It categorizes and discusses diverse NP types, including polymeric, lipid-based, and metallic nanoparticles, emphasizing their applications in enhancing the bioavailability and specificity of anticancer agents. This review also explores the integration of advanced technologies, such as theranostics and artificial intelligence, to optimize NP design and functionality for personalized medicine. However, challenges remain, including issues related to toxicity, drug resistance, and manufacturing scalability. Addressing these barriers re- quires interdisciplinary research focused on developing stimuli-responsive NPs, improving biocompatibility, and incorporating multimodal therapeutic platforms. Although substantial progress has been made, this review is limited by the paucity of clinical trials validating NP efficacy and safety in diverse patient populations. Fu- ture endeavors should prioritize translational research to bridge the gap between preclinical innovations and clinical applications, ensuring that these transformative technologies benefit a broader spectrum of cancer pa- tients. The review underscores the immense potential of NPs in redefining cancer treatment while advocating for sustained research to address existing limitations and unlock their full therapeutic promise. Bentham Science Publishers 2025-04-16 Article PeerReviewed application/pdf en http://irep.iium.edu.my/123745/1/123745_Nanoparticles%20as%20novel%20drug%20delivery.pdf application/pdf en http://irep.iium.edu.my/123745/2/123745_Nanoparticles%20as%20novel%20drug%20delivery_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/123745/3/123745_Nanoparticles%20as%20novel%20drug%20delivery_WOS.pdf Liew, Kai Bin and Phang, Hiu Ching and Tan, Vinie Ying Xuan and Kee, Phei Er and Ming, Long Chiau and Vijayaraj Kumar, Palanirajan and Lee, Siew-Keah and Helal Uddin, A.B.M. and Gilhotra, Ritu M. and Ramanunny, Arya Kadukkattil (2025) Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives. Current Pharmaceutical Design, 31 (39). pp. 3117-3127. ISSN 1381-6128 E-ISSN 1873-4286 https://www.eurekaselect.com/article/147710 10.2174/0113816128368718250320060346 |
| spellingShingle | QD Chemistry RM Therapeutics. Pharmacology RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Liew, Kai Bin Phang, Hiu Ching Tan, Vinie Ying Xuan Kee, Phei Er Ming, Long Chiau Vijayaraj Kumar, Palanirajan Lee, Siew-Keah Helal Uddin, A.B.M. Gilhotra, Ritu M. Ramanunny, Arya Kadukkattil Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives |
| title | Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives |
| title_full | Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives |
| title_fullStr | Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives |
| title_full_unstemmed | Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives |
| title_short | Nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives |
| title_sort | nanoparticles as novel drug delivery systems for cancer treatment: current status and future perspectives |
| topic | QD Chemistry RM Therapeutics. Pharmacology RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/123745/1/123745_Nanoparticles%20as%20novel%20drug%20delivery.pdf http://irep.iium.edu.my/123745/2/123745_Nanoparticles%20as%20novel%20drug%20delivery_SCOPUS.pdf http://irep.iium.edu.my/123745/3/123745_Nanoparticles%20as%20novel%20drug%20delivery_WOS.pdf http://irep.iium.edu.my/123745/ https://www.eurekaselect.com/article/147710 |
| url_provider | http://irep.iium.edu.my/ |