The intricate nexus: the relationship between oxidative stress and inflammation in obesity
Obesity, defined as excessive fat storage, is linked to chronic low-grade inflammation and increased reactive oxygen species (ROS) generation. Inflammatory cells, such as neutrophils and macrophages, produce ROS during oxidative bursts to attack infections. However, in obese people, increased ROS...
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Faculty of Medicine and Health Sciences, University Putra Malaysia
2025
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| Online Access: | http://irep.iium.edu.my/123737/7/123737_The%20intricate%20nexus.pdf http://irep.iium.edu.my/123737/13/123737_The%20intricate%20nexus_Scopus.pdf http://irep.iium.edu.my/123737/ https://medic.upm.edu.my/upload/dokumen/20251011121456MJMHS_1293.pdf |
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| author | Abu Hanifah, Nabihah Kuttulebbai Naina Mohamed Salam, Sirajudeen Ahmad Affandi, Khairunisa Abdullah, Nor Zamzila Buyong, Zunariah Abdul Rahim, Roslina Ahmad, Hajar Fauzan |
| author_facet | Abu Hanifah, Nabihah Kuttulebbai Naina Mohamed Salam, Sirajudeen Ahmad Affandi, Khairunisa Abdullah, Nor Zamzila Buyong, Zunariah Abdul Rahim, Roslina Ahmad, Hajar Fauzan |
| author_sort | Abu Hanifah, Nabihah |
| building | IIUM Library |
| collection | Institutional Repository |
| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | Obesity, defined as excessive fat storage, is linked to chronic low-grade inflammation and increased reactive oxygen
species (ROS) generation. Inflammatory cells, such as neutrophils and macrophages, produce ROS during oxidative
bursts to attack infections. However, in obese people, increased ROS generation in hypertrophic and hypoxic adipose tissue maintains a chronic inflammatory state. ROS and Damage-Associated Molecular Patterns (DAMPs) generated by stressed adipocytes activate inflammatory pathways and transcription factors, including nuclear factor-kappa B (NF-κB). Identifying such mechanisms highlights the possibility of targeting ROS generation and inflammatory
pathways to reduce chronic inflammation and enhance metabolic health in obesity. This review seeks to clarify the
complex link between oxidative stress, inflammation, and obesity. |
| format | Article |
| id | my.iium.irep-123737 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en en |
| publishDate | 2025 |
| publisher | Faculty of Medicine and Health Sciences, University Putra Malaysia |
| record_format | dspace |
| spelling | my.iium.irep-1237372025-11-10T04:11:43Z http://irep.iium.edu.my/123737/ The intricate nexus: the relationship between oxidative stress and inflammation in obesity Abu Hanifah, Nabihah Kuttulebbai Naina Mohamed Salam, Sirajudeen Ahmad Affandi, Khairunisa Abdullah, Nor Zamzila Buyong, Zunariah Abdul Rahim, Roslina Ahmad, Hajar Fauzan R Medicine (General) Obesity, defined as excessive fat storage, is linked to chronic low-grade inflammation and increased reactive oxygen species (ROS) generation. Inflammatory cells, such as neutrophils and macrophages, produce ROS during oxidative bursts to attack infections. However, in obese people, increased ROS generation in hypertrophic and hypoxic adipose tissue maintains a chronic inflammatory state. ROS and Damage-Associated Molecular Patterns (DAMPs) generated by stressed adipocytes activate inflammatory pathways and transcription factors, including nuclear factor-kappa B (NF-κB). Identifying such mechanisms highlights the possibility of targeting ROS generation and inflammatory pathways to reduce chronic inflammation and enhance metabolic health in obesity. This review seeks to clarify the complex link between oxidative stress, inflammation, and obesity. Faculty of Medicine and Health Sciences, University Putra Malaysia 2025-09-30 Article PeerReviewed application/pdf en http://irep.iium.edu.my/123737/7/123737_The%20intricate%20nexus.pdf application/pdf en http://irep.iium.edu.my/123737/13/123737_The%20intricate%20nexus_Scopus.pdf Abu Hanifah, Nabihah and Kuttulebbai Naina Mohamed Salam, Sirajudeen and Ahmad Affandi, Khairunisa and Abdullah, Nor Zamzila and Buyong, Zunariah and Abdul Rahim, Roslina and Ahmad, Hajar Fauzan (2025) The intricate nexus: the relationship between oxidative stress and inflammation in obesity. Malaysian Journal of Medicine and Health Sciences, 21 (5). pp. 365-374. ISSN 1675-8544 E-ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/20251011121456MJMHS_1293.pdf 10.47836/mjmhs.21.5.40 |
| spellingShingle | R Medicine (General) Abu Hanifah, Nabihah Kuttulebbai Naina Mohamed Salam, Sirajudeen Ahmad Affandi, Khairunisa Abdullah, Nor Zamzila Buyong, Zunariah Abdul Rahim, Roslina Ahmad, Hajar Fauzan The intricate nexus: the relationship between oxidative stress and inflammation in obesity |
| title | The intricate nexus: the relationship between oxidative stress and inflammation in obesity |
| title_full | The intricate nexus: the relationship between oxidative stress and inflammation in obesity |
| title_fullStr | The intricate nexus: the relationship between oxidative stress and inflammation in obesity |
| title_full_unstemmed | The intricate nexus: the relationship between oxidative stress and inflammation in obesity |
| title_short | The intricate nexus: the relationship between oxidative stress and inflammation in obesity |
| title_sort | intricate nexus: the relationship between oxidative stress and inflammation in obesity |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/123737/7/123737_The%20intricate%20nexus.pdf http://irep.iium.edu.my/123737/13/123737_The%20intricate%20nexus_Scopus.pdf http://irep.iium.edu.my/123737/ https://medic.upm.edu.my/upload/dokumen/20251011121456MJMHS_1293.pdf |
| url_provider | http://irep.iium.edu.my/ |