A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges
A 38-year-old Chinese gentleman presented to a private healthcare facility with a chief complaint of unilateral epistaxis, persisting for 2 months. An endoscopic examination revealed a polyp-like structure in the left nasal cavity, which bled upon contact. The patient underwent endoscopic sinus s...
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| Language: | en |
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Sciencedomain International
2025
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| Online Access: | http://irep.iium.edu.my/123719/13/123719_A%20case%20report%20on%20sinonasal.pdf http://irep.iium.edu.my/123719/ https://journaljcti.com/index.php/JCTI/article/view/323 |
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| author | Mariappen, Suraien Lim, Walter Yung Chwen Ng, Pui Foong Maruthamuthu, Thevagi Rozhan, 'Atikah |
| author_facet | Mariappen, Suraien Lim, Walter Yung Chwen Ng, Pui Foong Maruthamuthu, Thevagi Rozhan, 'Atikah |
| author_sort | Mariappen, Suraien |
| building | IIUM Library |
| collection | Institutional Repository |
| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | A 38-year-old Chinese gentleman presented to a private healthcare facility with a chief complaint of
unilateral epistaxis, persisting for 2 months. An endoscopic examination revealed a polyp-like
structure in the left nasal cavity, which bled upon contact. The patient underwent endoscopic sinus
surgery and biopsy. Initial histopathological examination rendered as well differentiated squamous
cell carcinoma. Post operatively, despite persistent nasal symptoms, the patient defaulted on
treatment. Two months later, he presented to the emergency department with painless, progressive
left eye swelling, accompanied by left eye vision loss, reduced hearing, and tinnitus for 1
week. Examination revealed proptosis of the left eye, firm and non tender swelling over the left
maxillary region, and a fleshy mass occupying the entire left nostril. Imaging studies showed
extensive disease involving the nasal cavity, paranasal sinuses, left orbit with intracranial
extension, and bony erosions. Histopathological examination from a biopsy confirmed Sinonasal
Undifferentiated Carcinoma (SNUC). The patient was staged as cT4bN0M0 and planned
for chemotherapy but defaulted after 2 cycles due to intolerable side effects. He succumbed
to locally advanced disease a month later. SNUC is a rare and highly aggressive malignant
neoplasm originating from the epithelial lining of the paranasal sinuses and nasal cavity. Its
aggressive nature often results in large and extensive tumors at the time of diagnosis, with a
short duration of symptoms. While initial treatment involves surgical resection, complete tumor
removal is often challenging due to complex anatomy. Aggressive multimodality treatment is
recommended, although SNUC carries a high rate of local recurrence and increased morbidity and
mortality. |
| format | Article |
| id | my.iium.irep-123719 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en |
| publishDate | 2025 |
| publisher | Sciencedomain International |
| record_format | dspace |
| spelling | my.iium.irep-1237192025-10-15T04:10:05Z http://irep.iium.edu.my/123719/ A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges Mariappen, Suraien Lim, Walter Yung Chwen Ng, Pui Foong Maruthamuthu, Thevagi Rozhan, 'Atikah RF Otorhinolaryngology A 38-year-old Chinese gentleman presented to a private healthcare facility with a chief complaint of unilateral epistaxis, persisting for 2 months. An endoscopic examination revealed a polyp-like structure in the left nasal cavity, which bled upon contact. The patient underwent endoscopic sinus surgery and biopsy. Initial histopathological examination rendered as well differentiated squamous cell carcinoma. Post operatively, despite persistent nasal symptoms, the patient defaulted on treatment. Two months later, he presented to the emergency department with painless, progressive left eye swelling, accompanied by left eye vision loss, reduced hearing, and tinnitus for 1 week. Examination revealed proptosis of the left eye, firm and non tender swelling over the left maxillary region, and a fleshy mass occupying the entire left nostril. Imaging studies showed extensive disease involving the nasal cavity, paranasal sinuses, left orbit with intracranial extension, and bony erosions. Histopathological examination from a biopsy confirmed Sinonasal Undifferentiated Carcinoma (SNUC). The patient was staged as cT4bN0M0 and planned for chemotherapy but defaulted after 2 cycles due to intolerable side effects. He succumbed to locally advanced disease a month later. SNUC is a rare and highly aggressive malignant neoplasm originating from the epithelial lining of the paranasal sinuses and nasal cavity. Its aggressive nature often results in large and extensive tumors at the time of diagnosis, with a short duration of symptoms. While initial treatment involves surgical resection, complete tumor removal is often challenging due to complex anatomy. Aggressive multimodality treatment is recommended, although SNUC carries a high rate of local recurrence and increased morbidity and mortality. Sciencedomain International 2025-09-15 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/123719/13/123719_A%20case%20report%20on%20sinonasal.pdf Mariappen, Suraien and Lim, Walter Yung Chwen and Ng, Pui Foong and Maruthamuthu, Thevagi and Rozhan, 'Atikah (2025) A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges. Journal of Cancer and Tumor International, 15 (4). pp. 71-78. ISSN 2454-7360 https://journaljcti.com/index.php/JCTI/article/view/323 10.9734/jcti/2025/v15i4323 |
| spellingShingle | RF Otorhinolaryngology Mariappen, Suraien Lim, Walter Yung Chwen Ng, Pui Foong Maruthamuthu, Thevagi Rozhan, 'Atikah A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges |
| title | A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges |
| title_full | A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges |
| title_fullStr | A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges |
| title_full_unstemmed | A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges |
| title_short | A case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges |
| title_sort | case report on sinonasal undifferentiated carcinoma: a surgeon’s challenge or simply treatment challenges |
| topic | RF Otorhinolaryngology |
| url | http://irep.iium.edu.my/123719/13/123719_A%20case%20report%20on%20sinonasal.pdf http://irep.iium.edu.my/123719/ https://journaljcti.com/index.php/JCTI/article/view/323 |
| url_provider | http://irep.iium.edu.my/ |