Vascular ultrastructural changes in hypertensive rodent models: a 15-year scoping review
Understanding ultrastructural changes in vascular tissue provides critical insights into the pathophysiology of hyper-tension, a leading global cause of mortality. This scoping review aims to offer a comprehensive overview of vascular ultrastructural changes in hypertensive rodent models over the pa...
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Universiti Putra Malaysia Press
2025
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| Online Access: | http://irep.iium.edu.my/123706/7/123706_Vascular%20ultrastructural%20changes%20in%20hypertensive%20rodent.pdf http://irep.iium.edu.my/123706/ https://medic.upm.edu.my/upload/dokumen/20251011120418MJMHS_0768.pdf |
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| author | Ismawi, Hidayatul Radziah Zulkiflee, Khodijah Yusoff Azmi Merican, Yusoff Sharizal Mohd. Zainudin, Maizura Abd. Fuaat, Azliana Zainal Abidin, Fadhilah |
| author_facet | Ismawi, Hidayatul Radziah Zulkiflee, Khodijah Yusoff Azmi Merican, Yusoff Sharizal Mohd. Zainudin, Maizura Abd. Fuaat, Azliana Zainal Abidin, Fadhilah |
| author_sort | Ismawi, Hidayatul Radziah |
| building | IIUM Library |
| collection | Institutional Repository |
| content_provider | International Islamic University Malaysia |
| content_source | IIUM Repository (IREP) |
| continent | Asia |
| country | Malaysia |
| description | Understanding ultrastructural changes in vascular tissue provides critical insights into the pathophysiology of hyper-tension, a leading global cause of mortality. This scoping review aims to offer a comprehensive overview of vascular ultrastructural changes in hypertensive rodent models over the past 15 years. Following the Arksey and O’Malley protocol, we conducted a scoping review of relevant literature. This involved defining research questions, identifying and selecting pertinent studies, data extraction, synthesis, and reporting. Searches encompassed Google Scholar, PubMed, Scopus, and Science Direct. Thirty studies were included, showcasing diverse methodologies, objectives,
and findings. These studies investigated various hypertensive models, different vessels, and multiple quantitative, semi-quantitative, and qualitative parameters of vascular ultrastructure, along with different intervention strategies. This review provides a synthesis of existing knowledge on vascular ultrastructural changes in hypertensive rodent models and discusses relevance of rodent models to human hypertension, functional implications of ultrastructural changes and pharmacological interventions targeting these changes thus serving as a resource for researchers studying hypertension pathophysiology to identify therapeutic targets or assess novel interventions. |
| format | Article |
| id | my.iium.irep-123706 |
| institution | Universiti Islam Antarabangsa Malaysia |
| language | en |
| publishDate | 2025 |
| publisher | Universiti Putra Malaysia Press |
| record_format | dspace |
| spelling | my.iium.irep-1237062025-10-14T07:54:00Z http://irep.iium.edu.my/123706/ Vascular ultrastructural changes in hypertensive rodent models: a 15-year scoping review Ismawi, Hidayatul Radziah Zulkiflee, Khodijah Yusoff Azmi Merican, Yusoff Sharizal Mohd. Zainudin, Maizura Abd. Fuaat, Azliana Zainal Abidin, Fadhilah QM Human anatomy R Medicine (General) RB Pathology Understanding ultrastructural changes in vascular tissue provides critical insights into the pathophysiology of hyper-tension, a leading global cause of mortality. This scoping review aims to offer a comprehensive overview of vascular ultrastructural changes in hypertensive rodent models over the past 15 years. Following the Arksey and O’Malley protocol, we conducted a scoping review of relevant literature. This involved defining research questions, identifying and selecting pertinent studies, data extraction, synthesis, and reporting. Searches encompassed Google Scholar, PubMed, Scopus, and Science Direct. Thirty studies were included, showcasing diverse methodologies, objectives, and findings. These studies investigated various hypertensive models, different vessels, and multiple quantitative, semi-quantitative, and qualitative parameters of vascular ultrastructure, along with different intervention strategies. This review provides a synthesis of existing knowledge on vascular ultrastructural changes in hypertensive rodent models and discusses relevance of rodent models to human hypertension, functional implications of ultrastructural changes and pharmacological interventions targeting these changes thus serving as a resource for researchers studying hypertension pathophysiology to identify therapeutic targets or assess novel interventions. Universiti Putra Malaysia Press 2025-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/123706/7/123706_Vascular%20ultrastructural%20changes%20in%20hypertensive%20rodent.pdf Ismawi, Hidayatul Radziah and Zulkiflee, Khodijah and Yusoff Azmi Merican, Yusoff Sharizal and Mohd. Zainudin, Maizura and Abd. Fuaat, Azliana and Zainal Abidin, Fadhilah (2025) Vascular ultrastructural changes in hypertensive rodent models: a 15-year scoping review. Malaysian Journal of Medicine and Health Sciences, 21 (5). pp. 302-309. ISSN 1675-8544 E-ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/20251011120418MJMHS_0768.pdf 10.47836/mjmhs.21.5.33 |
| spellingShingle | QM Human anatomy R Medicine (General) RB Pathology Ismawi, Hidayatul Radziah Zulkiflee, Khodijah Yusoff Azmi Merican, Yusoff Sharizal Mohd. Zainudin, Maizura Abd. Fuaat, Azliana Zainal Abidin, Fadhilah Vascular ultrastructural changes in hypertensive rodent models: a 15-year scoping review |
| title | Vascular ultrastructural changes in hypertensive rodent
models: a 15-year scoping review |
| title_full | Vascular ultrastructural changes in hypertensive rodent
models: a 15-year scoping review |
| title_fullStr | Vascular ultrastructural changes in hypertensive rodent
models: a 15-year scoping review |
| title_full_unstemmed | Vascular ultrastructural changes in hypertensive rodent
models: a 15-year scoping review |
| title_short | Vascular ultrastructural changes in hypertensive rodent
models: a 15-year scoping review |
| title_sort | vascular ultrastructural changes in hypertensive rodent
models: a 15-year scoping review |
| topic | QM Human anatomy R Medicine (General) RB Pathology |
| url | http://irep.iium.edu.my/123706/7/123706_Vascular%20ultrastructural%20changes%20in%20hypertensive%20rodent.pdf http://irep.iium.edu.my/123706/ https://medic.upm.edu.my/upload/dokumen/20251011120418MJMHS_0768.pdf |
| url_provider | http://irep.iium.edu.my/ |