A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer

Aim: Chromones are promising for anticancer drug development. Methods & results: 12 chromone-based compounds were synthesized and tested against cancer cell lines. Compound 8 showed the highest cytotoxicity (LC50 3.2 μM) against colorectal cancer cells, surpassing 5-fluorouracil (LC50 4.2 μM)...

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Main Authors:	Shamsudin, Nur Farisya, Leong, Sze-Wei, Koeberle, Andreas, Suriya, Utid, Rungrotmongkol, Thanyada, Chia, Suet Lin, Taher, Muhammad, Haris @ Harith, Muhammad Salahuddin, Alshwyeh, Hussah Abdullah, Alosaimi, Areej A, Mediani, Ahmed, Ilowefah, Muna Abdulsalam, Islami, Deri, Mohd Faudzi, Siti Munirah, Mohd Aluwi, Mohd Fadhlizil Fasihi, Wai, Lam Kok, Rullah, Kamal
Format:	Article
Language:	en en en
Published:	Taylor and Francis Ltd. 2024
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/115427/19/115427_A%20novel%20chromone-based%20as%20a%20potential%20inhibitor%20of%20ULK1%20that%20modulates%20autophagy%20and%20induces%20apoptosis%20in%20colon%20cancer.pdf http://irep.iium.edu.my/115427/20/115427_A%20novel%20chromone-based%20as%20a%20potential%20inhibitor%20of%20ULK1%20that%20modulates%20autophagy%20and%20induces%20apoptosis%20in%20colon%20cancer_Scopus.pdf http://irep.iium.edu.my/115427/21/115427_A%20novel%20chromone-based%20as%20a%20potential%20inhibitor%20of%20ULK1%20that%20modulates%20autophagy%20and%20induces%20apoptosis%20in%20colon%20cancer_WoS.pdf http://irep.iium.edu.my/115427/ https://www.tandfonline.com/doi/abs/10.1080/17568919.2024.2363668
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