Treatment of osteoarthritis using Synvisc in New Zealand white rabbit
INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide. Synvisc® is wildly used as a treatment for OA. This study will investigate the histological changes of OA in rabbits treated with Synvisc®. MATERIALS & METHODS: Twelve NZWR underwent surgery to in...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | en |
| Published: |
Malaysian Orthopaedic Association
2023
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/109582/7/109582_Treatment%20of%20osteoarthritis%20using%20Synvisc%20in%20New%20Zealand%20white%20rabbit.pdf http://irep.iium.edu.my/109582/ https://www.morthoj.org/supplements/moa-2023/Poster/Ortho-Research/ER12.pdf |
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| Summary: | INTRODUCTION: Osteoarthritis (OA) is a degenerative joint disease affecting millions worldwide. Synvisc® is wildly used as a treatment for OA. This study will investigate the histological changes of OA in rabbits treated with Synvisc®.
MATERIALS & METHODS: Twelve NZWR underwent surgery to induce OA. The rabbits were injected with intraarticular Synvisc® after 3 weeks. It is then euthanized at 3, 6, 12 and 24 weeks according to its group. The knee joint samples were collected and underwent hard tissue processing. The specimens were stained with Masson-Goldner staining.
RESULTS: No intraoperative complications were observed. The Synvisc®-treated OA knees at 6 weeks (Figure 1) and at 12 (Figure 2) exhibited no inflammation. Improvement of cartilage thickness was noted. The cartilage is thicker in 12 weeks group compared to 6 weeks group.
DISCUSSION: Rabbits treated with Synvisc® had less cartilage degeneration. This cartilage improvement was observed at 6 and 12 weeks after treatment. Specifically, the rabbits treated with Synvisc® improved the cartilage thickness.
CONCLUSION: Synvisc® treatment showed histological improvements of OA in rabbits. |
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