Impact of GSK199 and GSK106 binding on protein arginine deiminase IV stability and flexibility: a computational approach

Protein arginine deiminase IV (PAD4) is a potential target for diseases including rheumatoid arthritis and cancers. Currently, GSK199 is a potent, selective yet reversible PAD4 inhibitor. Its derivative, GSK106, on the other hand, was reported as an inactive compound when tested against PAD4 assay....

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Bibliographic Details

Main Authors:	Zainal Fithri, Helmi Husaini, Ibrahim, Zalikha, Ali, Ernie Zuraida
Format:	Article
Language:	en en
Published:	Elsevier Ltd. 2023
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/107889/7/107889_Impact%20of%20GSK199%20and%20GSK106%20binding%20on%20protein%20arginine.pdf http://irep.iium.edu.my/107889/8/107889_Impact%20of%20GSK199%20and%20GSK106%20binding%20on%20protein%20arginine_Scopus.pdf http://irep.iium.edu.my/107889/ https://www.sciencedirect.com/science/article/abs/pii/S1476927123001536 https://doi.org/10.1016/j.compbiolchem.2023.107962
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