Revisiting genetics of cleft lip with or without cleft palate and cleft palate only: a narrative review
Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are the most common orofacial deformities observed in humans where almost 1 in 700 to 1 in 2000 babies born each year are affected worldwide. This condition occurs when the specific and independently derived facial primordia...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | en |
| Published: |
Penerbit Universiti Sains Malaysia
2023
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/107536/14/107536_Revisiting%20genetics%20of%20cleft%20lip%20with%20or%20without%20cleft%20palate.pdf http://irep.iium.edu.my/107536/ https://aos.usm.my/docs/Vol_18/aos-2023-0018.pdf https://doi.org/10.21315/aos2023.1802.RV01 |
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| Summary: | Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are the most common orofacial
deformities observed in humans where almost 1 in 700 to 1 in 2000 babies born each year are affected
worldwide. This condition occurs when the specific and independently derived facial primordial fails to
fuse together, hence forming the cleft of the lip and palate or the palate alone. These orofacial
abnormalities can be divided into syndromic and non-syndromic where the deformities are either
associated with other disorders or present on their own, respectively. It is important to understand every
step in the lip and palate development during embryonic stage to pinpoint the exact problem affecting the
normal development of the human face. With current technologies, more genes are identified to be
associated and caused CLP and CP in humans. Therefore, this review aimed to elaborate the latest
updates on the genetics of CLP and CP. Polymorphism in some of the genes has been associated with the
incidence of these anomalies. Identification of these genes provides new knowledge on how these
craniofacial abnormalities occur and hopefully will enable earlier treatment of these deformities to be
implemented. |
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