A mini-review on the insight into the effect of natural and Synthetic α,β-unsaturated carbonyl-containing compounds on PI3K/AKT/mTOR signaling pathways to treat breast cancer
Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en en en |
| Published: |
World Scientific
2022
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/101414/19/101414_A%20mini-review%20on%20the%20insight.pdf http://irep.iium.edu.my/101414/20/101414_A%20mini-review%20on%20the%20insight_SCOPUS.pdf http://irep.iium.edu.my/101414/21/101414_A%20mini-review%20on%20the%20insight_WOS.pdf http://irep.iium.edu.my/101414/ https://www.worldscientific.com/worldscinet/jcbc |
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| Summary: | Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of different cancer, making it a critical target for cancer treatment. Inhibition of the mTOR protein kinase can cause autophagic cell death. It is known that covalent inhibitors have become a prominent issue in drug discovery, with covalent inhibitors focusing on �; �-unsaturated carbonyl molecules. Structural modifications to �; �-unsaturated carbonyl may be one of the finest avenues for developing the best breast cancer medication. This review article discusses recent research on natural and
synthetic �; �-unsaturated carbonyls and their anti-cancer properties targeting on mTOR, with SAR to showcase the
efficacy of synthetic natural products compared to parental compounds using both biological assays and in silico studies. |
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