Targeting PCSK9: bioinformatics analysis reveals functionally damaging missense variants

Proprotein convertase subtilisin/kexin type 9 (PCSK9) modulates cholesterol homeostasis by targeting low-density lipoprotein receptor (LDLR) for lysosomal degradation. Genetic polymorphisms in PCSK9 can alter its autocatalytic processing, secretion, or binding affinity to LDLR. Reduce binding effici...

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Bibliographic Details

Main Authors:	Loo, Keat Wei, Huey, Chyi Loh, Griffiths, Lyn R.
Format:	Article
Language:	en
Published:	Penerbit Universiti Kebangsaan Malaysia 2025
Online Access:	http://journalarticle.ukm.my/26543/1/ML%2017.pdf http://journalarticle.ukm.my/26543/ https://jms.mabjournal.com/index.php/mab/issue/view/69
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