Targeting PCSK9: bioinformatics analysis reveals functionally damaging missense variants
Proprotein convertase subtilisin/kexin type 9 (PCSK9) modulates cholesterol homeostasis by targeting low-density lipoprotein receptor (LDLR) for lysosomal degradation. Genetic polymorphisms in PCSK9 can alter its autocatalytic processing, secretion, or binding affinity to LDLR. Reduce binding effici...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | en |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2025
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| Online Access: | http://journalarticle.ukm.my/26543/1/ML%2017.pdf http://journalarticle.ukm.my/26543/ https://jms.mabjournal.com/index.php/mab/issue/view/69 |
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