Synthesis, acetylcholinesterase and molecular modelling analysis of (3E,5E)-3,5-Diarylidene-1-Phenylethylpiperidine-4-one derivatives as a therapeutic agent for Alzheimer’s disease

New diarylidiene-1-phenylethylpiperidine-4-one derivatives 2a-h were successfully synthesised with yields ranging from 57% to 96% and characterised with various spectroscopic methods. The compounds were evaluated for their in vitro acetylcholinesterase inhibition activity with galantamine as positiv...

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Bibliographic Details

Main Authors:	Mohd Khairul Nizam Mazlan, Mohamad Nurul Azmi, Mohd Salleh Rofiee, Muntaz Abu Bakar, Muhammad Solehin Abd Ghani, Mohammed Tasyriq Che Omar, Thaigarajan Parumasivam, Mohd Fazli Mohammat, Wibowo, Agustono
Format:	Article
Language:	en
Published:	Penerbit Universiti Kebangsaan Malaysia 2025
Online Access:	http://journalarticle.ukm.my/26517/1/SSS%2010.pdf http://journalarticle.ukm.my/26517/ https://www.ukm.my/jsm/english_journals/vol54num11_2025/contentsVol54num11_2025.html
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