Synthesis and evaluation of para-substituted bis(Arylidene)cycloalkanones as potential α-Amylase inhibitor with molecular docking and ADMET profiling

Ten para-substituted bis(arylidene)cycloalkanone derivatives were synthesised, characterised and their inhibitory activities against human pancreatic α-amylase were evaluated. Among them, halogen-substituted derivatives 5d (IC50 = 7.6 ± 1.4 µM) and 5e (IC50 = 6.9 ± 1.8 µM) exhibited superior potency...

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Bibliographic Details

Main Authors:	Nur Farah Atiqah Azmi, Mohamad Nurul Azmi, Mahdi Babai, Mohamad Hafizi Abu Bakar, Muntaz Abu Bakar, Mohammad Tasyriq Che Omar
Format:	Article
Language:	en
Published:	Penerbit Universiti Kebangsaan Malaysia 2025
Online Access:	http://journalarticle.ukm.my/26324/1/SMS%208.pdf http://journalarticle.ukm.my/26324/ https://www.ukm.my/jsm/english_journals/vol54num9_2025/contentsVol54num9_2025.html
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