An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth
Celastrus hindsii Benth., a medicinal plant celebrated for its traditionally medicinal and practically therapeutic properties, has been used for generations in Vietnam to support the treatment of ulcers, tumors, and inflammation. The difference between several phenotypes, primarily identified as Bro...
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| Language: | en |
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Penerbit Universiti Kebangsaan Malaysia
2024
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| Online Access: | http://journalarticle.ukm.my/23564/1/MJ%203.pdf http://journalarticle.ukm.my/23564/ https://jms.mabjournal.com/index.php/mab/issue/view/58 |
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| author | Nguyen, Van Huy Pham, Thanh Loan |
| author_facet | Nguyen, Van Huy Pham, Thanh Loan |
| author_sort | Nguyen, Van Huy |
| building | Tun Sri Lanang Library |
| collection | Institutional Repository |
| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Celastrus hindsii Benth., a medicinal plant celebrated for its traditionally medicinal and practically therapeutic properties, has been used for generations in Vietnam to support the treatment of ulcers, tumors, and inflammation. The difference between several phenotypes, primarily identified as Broad Leaf (BL) and Narrow Leaf (NL), has been clarified by convincing scientific evidence through our previous proteomics study, which also revealed several bioactive proteins and peptides. Therefore, based on the findings, this study further investigated their therapeutic properties using a bioinformatics tool (BLASTP) and analyzing literature data. The results showed the distinguished variations in protein profile between the NL and BL proteomes and revealed five significant proteins with therapeutic properties. Of these, three proteins can have anti-tumor and anti-inflammatory activity and have been proven effective in cancer treatment. Therefore, C. hindsii, particularly the BL phenotype with elevated levels of therapeutic proteins, could be a promising plant candidate for future intensive research and applications for cancer treatment. |
| format | Article |
| id | my-ukm.journal.23564 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2024 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my-ukm.journal.235642024-05-17T02:34:09Z http://journalarticle.ukm.my/23564/ An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth Nguyen, Van Huy Pham, Thanh Loan Celastrus hindsii Benth., a medicinal plant celebrated for its traditionally medicinal and practically therapeutic properties, has been used for generations in Vietnam to support the treatment of ulcers, tumors, and inflammation. The difference between several phenotypes, primarily identified as Broad Leaf (BL) and Narrow Leaf (NL), has been clarified by convincing scientific evidence through our previous proteomics study, which also revealed several bioactive proteins and peptides. Therefore, based on the findings, this study further investigated their therapeutic properties using a bioinformatics tool (BLASTP) and analyzing literature data. The results showed the distinguished variations in protein profile between the NL and BL proteomes and revealed five significant proteins with therapeutic properties. Of these, three proteins can have anti-tumor and anti-inflammatory activity and have been proven effective in cancer treatment. Therefore, C. hindsii, particularly the BL phenotype with elevated levels of therapeutic proteins, could be a promising plant candidate for future intensive research and applications for cancer treatment. Penerbit Universiti Kebangsaan Malaysia 2024 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/23564/1/MJ%203.pdf Nguyen, Van Huy and Pham, Thanh Loan (2024) An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth. Malaysian Applied Biology, 53 (1). pp. 35-43. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/issue/view/58 |
| spellingShingle | Nguyen, Van Huy Pham, Thanh Loan An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth |
| title | An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth |
| title_full | An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth |
| title_fullStr | An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth |
| title_full_unstemmed | An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth |
| title_short | An in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii Benth |
| title_sort | in silico approach for identification of potential therapeutic targets for cancer treatment from celastrus hindsii benth |
| url | http://journalarticle.ukm.my/23564/1/MJ%203.pdf http://journalarticle.ukm.my/23564/ https://jms.mabjournal.com/index.php/mab/issue/view/58 |
| url_provider | http://journalarticle.ukm.my/ |