Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and co...
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Penerbit Universiti Kebangsaan Malaysia
2021
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| Online Access: | http://journalarticle.ukm.my/17420/1/23.pdf http://journalarticle.ukm.my/17420/ https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html |
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| author | Nur Fatin Nabilah Mohd Sahardi, Faizul Jaafar, Siti Nor Asyikin Zakaria, Tan, Jen Kit Mariam Firdhaus Mad Nordin, Suzana Makpol, |
| author_facet | Nur Fatin Nabilah Mohd Sahardi, Faizul Jaafar, Siti Nor Asyikin Zakaria, Tan, Jen Kit Mariam Firdhaus Mad Nordin, Suzana Makpol, |
| author_sort | Nur Fatin Nabilah Mohd Sahardi, |
| building | Tun Sri Lanang Library |
| collection | Institutional Repository |
| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory,
and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products
are still lacking. This study aimed to analyse and compare the antioxidant properties of two types of Malaysian ginger
extracts (GE1 and GE2) with that of selected natural products. The antioxidant activities were measured by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric reducing antioxidant power (FRAP) assays, while cell viability was
determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonyl)-2H-tetrazolium (MTS) assay.
The order of the DPPH scavenging activities was as follows: vitamin C > palm tocotrienol-rich fraction (TRF) >
α-tocopherol > N-acetylcysteine (NAC) > Ficus deltoidea > butylated hydroxytoluene (BHT) > Centella asiatica > GE2
> GE1 > Moringa oleifera > Kelulut honey; the order of the mean FRAP value was as follows: NAC > α-tocopherol >
BHT > TRF > Ficus deltoidea > Moringa oleifera > GE2 = GE1 > Centella asiatica > Kelulut honey. The viability assays
showed that both ginger extracts significantly increased the percentage of viable cells (p < 0.05). In conclusion, neither
of the ginger extracts was cytotoxic toward cells and both possessed comparable antioxidant properties, indicating
their potential for ameliorating oxidative stress. |
| format | Article |
| id | my-ukm.journal.17420 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2021 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my-ukm.journal.174202021-09-14T03:13:02Z http://journalarticle.ukm.my/17420/ Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture Nur Fatin Nabilah Mohd Sahardi, Faizul Jaafar, Siti Nor Asyikin Zakaria, Tan, Jen Kit Mariam Firdhaus Mad Nordin, Suzana Makpol, Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and compare the antioxidant properties of two types of Malaysian ginger extracts (GE1 and GE2) with that of selected natural products. The antioxidant activities were measured by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric reducing antioxidant power (FRAP) assays, while cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonyl)-2H-tetrazolium (MTS) assay. The order of the DPPH scavenging activities was as follows: vitamin C > palm tocotrienol-rich fraction (TRF) > α-tocopherol > N-acetylcysteine (NAC) > Ficus deltoidea > butylated hydroxytoluene (BHT) > Centella asiatica > GE2 > GE1 > Moringa oleifera > Kelulut honey; the order of the mean FRAP value was as follows: NAC > α-tocopherol > BHT > TRF > Ficus deltoidea > Moringa oleifera > GE2 = GE1 > Centella asiatica > Kelulut honey. The viability assays showed that both ginger extracts significantly increased the percentage of viable cells (p < 0.05). In conclusion, neither of the ginger extracts was cytotoxic toward cells and both possessed comparable antioxidant properties, indicating their potential for ameliorating oxidative stress. Penerbit Universiti Kebangsaan Malaysia 2021-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/17420/1/23.pdf Nur Fatin Nabilah Mohd Sahardi, and Faizul Jaafar, and Siti Nor Asyikin Zakaria, and Tan, Jen Kit and Mariam Firdhaus Mad Nordin, and Suzana Makpol, (2021) Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture. Sains Malaysiana, 50 (5). pp. 1445-1456. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html |
| spellingShingle | Nur Fatin Nabilah Mohd Sahardi, Faizul Jaafar, Siti Nor Asyikin Zakaria, Tan, Jen Kit Mariam Firdhaus Mad Nordin, Suzana Makpol, Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture |
| title | Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture |
| title_full | Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture |
| title_fullStr | Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture |
| title_full_unstemmed | Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture |
| title_short | Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture |
| title_sort | comparison of the antioxidant activity of malaysian ginger (zingiber officinale roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture |
| url | http://journalarticle.ukm.my/17420/1/23.pdf http://journalarticle.ukm.my/17420/ https://www.ukm.my/jsm/malay_journals/jilid50bil5_2021/KandunganJilid50Bil5_2021.html |
| url_provider | http://journalarticle.ukm.my/ |