Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury
Multiple pathomechanisms of cerebral ischemia reperfusion (I/R) injuries can be ameliorated by certain high-potential pharmaceutical substances. In the present study, we investigated the acute effect of p-hydroxycinnamic (pHCA) acid against cerebral I/R injury in mice. Thirty male ICR mice were divi...
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Penerbit Universiti Kebangsaan Malaysia
2019
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| Online Access: | http://journalarticle.ukm.my/14401/1/18%20Romgase%20Sakamula.pdf http://journalarticle.ukm.my/14401/ http://www.ukm.my/jsm/malay_journals/jilid48bil10_2019/KandunganJilid48Bil10_2019.htm |
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| author | Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa, |
| author_facet | Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa, |
| author_sort | Romgase Sakamula, |
| building | Tun Sri Lanang Library |
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| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Multiple pathomechanisms of cerebral ischemia reperfusion (I/R) injuries can be ameliorated by certain high-potential pharmaceutical substances. In the present study, we investigated the acute effect of p-hydroxycinnamic (pHCA) acid against cerebral I/R injury in mice. Thirty male ICR mice were divided into Sham, Control-I/R, and pHCA-I/R groups. The pHCA 100 mg/kg and the vehicle were given 30 min before I/R induction. Thirty-minute bilateral common carotid artery occlusion followed by 45-min reperfusion was performed on the Control-I/R and pHCA-I/R groups. Brains were collected for biochemical analysis, infarction and histological study of the cerebral cortex and corpus callosum (CC). The results showed that I/R induction significantly induced biochemical changes (p<0.05) along with the increase of brain infarction (p<0.05), percentage of degeneration in cerebral cortex (p<0.05) and decrease of CC white matter density (p<0.05). Pretreatment with pHCA significantly reduced MDA (p<0.05), brain infarction (p<0.05), cerebral cortex neuronal degeneration (p<0.05) and prevented the reduction of white matter density in the CC (p<0.05). The present study concluded that pretreatment with pHCA helps prevent cerebral I/R injury by amelioration of lipid peroxidation, white matter damage and neuronal degeneration. |
| format | Article |
| id | my-ukm.journal.14401 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2019 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my-ukm.journal.144012020-03-10T02:34:23Z http://journalarticle.ukm.my/14401/ Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa, Multiple pathomechanisms of cerebral ischemia reperfusion (I/R) injuries can be ameliorated by certain high-potential pharmaceutical substances. In the present study, we investigated the acute effect of p-hydroxycinnamic (pHCA) acid against cerebral I/R injury in mice. Thirty male ICR mice were divided into Sham, Control-I/R, and pHCA-I/R groups. The pHCA 100 mg/kg and the vehicle were given 30 min before I/R induction. Thirty-minute bilateral common carotid artery occlusion followed by 45-min reperfusion was performed on the Control-I/R and pHCA-I/R groups. Brains were collected for biochemical analysis, infarction and histological study of the cerebral cortex and corpus callosum (CC). The results showed that I/R induction significantly induced biochemical changes (p<0.05) along with the increase of brain infarction (p<0.05), percentage of degeneration in cerebral cortex (p<0.05) and decrease of CC white matter density (p<0.05). Pretreatment with pHCA significantly reduced MDA (p<0.05), brain infarction (p<0.05), cerebral cortex neuronal degeneration (p<0.05) and prevented the reduction of white matter density in the CC (p<0.05). The present study concluded that pretreatment with pHCA helps prevent cerebral I/R injury by amelioration of lipid peroxidation, white matter damage and neuronal degeneration. Penerbit Universiti Kebangsaan Malaysia 2019-10 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14401/1/18%20Romgase%20Sakamula.pdf Romgase Sakamula, and Chanikarn Sakdapitak, and Wachiryah Thong-asa, (2019) Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury. Sains Malaysiana, 48 (10). pp. 2221-2227. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil10_2019/KandunganJilid48Bil10_2019.htm |
| spellingShingle | Romgase Sakamula, Chanikarn Sakdapitak, Wachiryah Thong-asa, Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury |
| title | Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury |
| title_full | Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury |
| title_fullStr | Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury |
| title_full_unstemmed | Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury |
| title_short | Effect of P-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury |
| title_sort | effect of p-hydroxycinnamic acid in mice model of cerebral ischemia-reperfusion injury |
| url | http://journalarticle.ukm.my/14401/1/18%20Romgase%20Sakamula.pdf http://journalarticle.ukm.my/14401/ http://www.ukm.my/jsm/malay_journals/jilid48bil10_2019/KandunganJilid48Bil10_2019.htm |
| url_provider | http://journalarticle.ukm.my/ |