Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats
Cisplatin is a chemotherapeutic agent widely used in treating various types of cancer. However, its usage is restricted due to the adverse hepatoxicity, as seen in approximately 36% of cancer patients receiving cisplatin treatment. Polygonum minus essential oil has high antioxidant capacity, and is...
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Penerbit Universiti Kebangsaan Malaysia
2019
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| Online Access: | http://journalarticle.ukm.my/14352/1/19%20Norhashima%20Abd%20Rashid.pdf http://journalarticle.ukm.my/14352/ http://www.ukm.my/jsm/malay_journals/jilid48bil9_2019/KandunganJilid48Bil9_2019.html |
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| author | Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Teoh, Seong Lin Siti Balkis Budin, |
| author_facet | Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Teoh, Seong Lin Siti Balkis Budin, |
| author_sort | Norhashima Abd Rashid, |
| building | Tun Sri Lanang Library |
| collection | Institutional Repository |
| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Cisplatin is a chemotherapeutic agent widely used in treating various types of cancer. However, its usage is restricted due to the adverse hepatoxicity, as seen in approximately 36% of cancer patients receiving cisplatin treatment. Polygonum minus essential oil has high antioxidant capacity, and is enriched with terpenoids and phenolic compounds. The objective of this study was to investigate effects of P. minus essential oil (PmEO) supplementation on cisplatin-induced hepatotoxicity in rats. Male rats were divided into seven different groups, namely: control (C), cisplatin-induced (CP), positive control with β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg (PmEO100CP), PmEO 200 mg/kg (PmEO200CP), PmEO 400 mg/kg (PmEO400CP) and PmEO 400 mg/kg alone (PmEO400). PmEO and BCP was given orally for 14 days prior to a single dose cisplatin (10 mg/kg) injection on day 15 and rats were sacrificed on day 18. Liver enzymes, histology, ultrastructural morphology and oxidative stress markers such as glutathione, glutathione peroxidase, catalase, superoxide dismutase and malondialdehyde were assayed. Compared to controls, levels of transaminase enzymes, serum bilirubin and oxidative stress were all increased in CP, PmEO200CP and PmEO400CP groups. However, only PmEO100CP and BCP groups reduced these increases in level of transaminase enzymes and oxidative stress compared to CP group. On both light microscopic and ultrastructural examination, CP and PmEO400CP groups showed hepatotoxicity, exhibited by cytoplasmic vacuolation, congested blood sinusoids and increased number of Kupffer cells. However, these changes were minimized in the PmEO100CP group. Therefore, we concluded that PmEO given at 100 mg/kg has preventive effect against cisplatin-induced hepatotoxicity in rats. |
| format | Article |
| id | my-ukm.journal.14352 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2019 |
| publisher | Penerbit Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my-ukm.journal.143522020-03-03T08:04:48Z http://journalarticle.ukm.my/14352/ Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Teoh, Seong Lin Siti Balkis Budin, Cisplatin is a chemotherapeutic agent widely used in treating various types of cancer. However, its usage is restricted due to the adverse hepatoxicity, as seen in approximately 36% of cancer patients receiving cisplatin treatment. Polygonum minus essential oil has high antioxidant capacity, and is enriched with terpenoids and phenolic compounds. The objective of this study was to investigate effects of P. minus essential oil (PmEO) supplementation on cisplatin-induced hepatotoxicity in rats. Male rats were divided into seven different groups, namely: control (C), cisplatin-induced (CP), positive control with β-caryophyllene 150 mg/kg (BCP), PmEO 100 mg/kg (PmEO100CP), PmEO 200 mg/kg (PmEO200CP), PmEO 400 mg/kg (PmEO400CP) and PmEO 400 mg/kg alone (PmEO400). PmEO and BCP was given orally for 14 days prior to a single dose cisplatin (10 mg/kg) injection on day 15 and rats were sacrificed on day 18. Liver enzymes, histology, ultrastructural morphology and oxidative stress markers such as glutathione, glutathione peroxidase, catalase, superoxide dismutase and malondialdehyde were assayed. Compared to controls, levels of transaminase enzymes, serum bilirubin and oxidative stress were all increased in CP, PmEO200CP and PmEO400CP groups. However, only PmEO100CP and BCP groups reduced these increases in level of transaminase enzymes and oxidative stress compared to CP group. On both light microscopic and ultrastructural examination, CP and PmEO400CP groups showed hepatotoxicity, exhibited by cytoplasmic vacuolation, congested blood sinusoids and increased number of Kupffer cells. However, these changes were minimized in the PmEO100CP group. Therefore, we concluded that PmEO given at 100 mg/kg has preventive effect against cisplatin-induced hepatotoxicity in rats. Penerbit Universiti Kebangsaan Malaysia 2019-09 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/14352/1/19%20Norhashima%20Abd%20Rashid.pdf Norhashima Abd Rashid, and Farida Hussan, and Asmah Hamid, and Nurul Raudzah Adib Ridzuan, and Teoh, Seong Lin and Siti Balkis Budin, (2019) Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats. Sains Malaysiana, 48 (9). pp. 1975-1988. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid48bil9_2019/KandunganJilid48Bil9_2019.html |
| spellingShingle | Norhashima Abd Rashid, Farida Hussan, Asmah Hamid, Nurul Raudzah Adib Ridzuan, Teoh, Seong Lin Siti Balkis Budin, Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats |
| title | Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats |
| title_full | Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats |
| title_fullStr | Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats |
| title_full_unstemmed | Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats |
| title_short | Preventive effects of Polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats |
| title_sort | preventive effects of polygonum minus essential oil on cisplatin-induced hepatotoxicity in sprague dawley rats |
| url | http://journalarticle.ukm.my/14352/1/19%20Norhashima%20Abd%20Rashid.pdf http://journalarticle.ukm.my/14352/ http://www.ukm.my/jsm/malay_journals/jilid48bil9_2019/KandunganJilid48Bil9_2019.html |
| url_provider | http://journalarticle.ukm.my/ |