Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using response surface methodology
γ-linolenic acid is an essential omega-6 unsaturated fatty acid made in the human body from linoleic acid. It can be metabolized to various important eicosanoids and it is also a precursor of prostaglandin E and several other active substances that are associated with anti-inflammatory properties. A...
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Universiti Kebangsaan Malaysia
2015
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| Online Access: | http://journalarticle.ukm.my/9496/1/12_Yao-Chang_Hsueh.pdf http://journalarticle.ukm.my/9496/ http://www.ukm.my/jsm/malay_journals/jilid44bil12_2015/KandunganJilid44Bil12_2015.html |
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| author | Yao, Ching Hsueh Be, Jen Wang Zer, Ran Yu Cheng, Chi Wang Malcolm Koo, |
| author_facet | Yao, Ching Hsueh Be, Jen Wang Zer, Ran Yu Cheng, Chi Wang Malcolm Koo, |
| author_sort | Yao, Ching Hsueh |
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| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | γ-linolenic acid is an essential omega-6 unsaturated fatty acid made in the human body from linoleic acid. It can be metabolized to various important eicosanoids and it is also a precursor of prostaglandin E and several other active substances that are associated with anti-inflammatory properties. Arthrospira platensis is known to contain relatively large quantities of γ-linolenic acid. The aim of this study was to investigate the optimal parameters under a continuous preparation method of γ-linolenic acid from A. platensis using supercritical carbon dioxide technology. A Box-Behnken experimental design and response surface methodology were used to optimize combinations among pressure (10, 20 and 30 MPa), temperature (40, 50 and 60°C) and flow rate of A. platensis extract liquor (1, 2 and 3 mL/min) for yield of γ-linolenic acid. The results showed that the extraction of γ-linolenic acid from A. platensis was optimized at a temperature of 60°C, a pressure of 30 MPa and a flow rate of 3 mL/min. These parameters could be used as a basis for facilitating future scale-up industrial applications. |
| format | Article |
| id | my-ukm.journal-9496 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2015 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my-ukm.journal-94962016-12-14T06:50:06Z http://journalarticle.ukm.my/9496/ Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using response surface methodology Yao, Ching Hsueh Be, Jen Wang Zer, Ran Yu Cheng, Chi Wang Malcolm Koo, γ-linolenic acid is an essential omega-6 unsaturated fatty acid made in the human body from linoleic acid. It can be metabolized to various important eicosanoids and it is also a precursor of prostaglandin E and several other active substances that are associated with anti-inflammatory properties. Arthrospira platensis is known to contain relatively large quantities of γ-linolenic acid. The aim of this study was to investigate the optimal parameters under a continuous preparation method of γ-linolenic acid from A. platensis using supercritical carbon dioxide technology. A Box-Behnken experimental design and response surface methodology were used to optimize combinations among pressure (10, 20 and 30 MPa), temperature (40, 50 and 60°C) and flow rate of A. platensis extract liquor (1, 2 and 3 mL/min) for yield of γ-linolenic acid. The results showed that the extraction of γ-linolenic acid from A. platensis was optimized at a temperature of 60°C, a pressure of 30 MPa and a flow rate of 3 mL/min. These parameters could be used as a basis for facilitating future scale-up industrial applications. Universiti Kebangsaan Malaysia 2015-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/9496/1/12_Yao-Chang_Hsueh.pdf Yao, Ching Hsueh and Be, Jen Wang and Zer, Ran Yu and Cheng, Chi Wang and Malcolm Koo, (2015) Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using response surface methodology. Sains Malaysiana, 44 (12). pp. 1739-1744. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid44bil12_2015/KandunganJilid44Bil12_2015.html |
| spellingShingle | Yao, Ching Hsueh Be, Jen Wang Zer, Ran Yu Cheng, Chi Wang Malcolm Koo, Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using response surface methodology |
| title | Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using
response surface methodology |
| title_full | Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using
response surface methodology |
| title_fullStr | Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using
response surface methodology |
| title_full_unstemmed | Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using
response surface methodology |
| title_short | Optimization of a Continuous Preparation Method of Arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using
response surface methodology |
| title_sort | optimization of a continuous preparation method of arthrospira platensis γ-linolenic acid by supercritical carbon dioxide technology using
response surface methodology |
| url | http://journalarticle.ukm.my/9496/1/12_Yao-Chang_Hsueh.pdf http://journalarticle.ukm.my/9496/ http://www.ukm.my/jsm/malay_journals/jilid44bil12_2015/KandunganJilid44Bil12_2015.html |
| url_provider | http://journalarticle.ukm.my/ |