Kesan in vitro rilmenidine ke atas rembesan insulin
This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | en |
| Published: |
penerbit ukm
2003
|
| Online Access: | http://journalarticle.ukm.my/948/1/jurnal4.pdf http://journalarticle.ukm.my/948/ http://www.fskb.ukm.my/fskbold/jurnal |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1831353101153468416 |
|---|---|
| author | Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, |
| author_facet | Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, |
| author_sort | Rosnani Hashim, |
| building | Tun Sri Lanang Library |
| collection | Institutional Repository |
| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. |
| format | Article |
| id | my-ukm.journal-948 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2003 |
| publisher | penerbit ukm |
| record_format | eprints |
| spelling | my-ukm.journal-9482016-12-14T06:28:23Z http://journalarticle.ukm.my/948/ Kesan in vitro rilmenidine ke atas rembesan insulin Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. penerbit ukm 2003-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/948/1/jurnal4.pdf Rosnani Hashim, and Tariq Abdul Razak, and Suhaimi Hashim, (2003) Kesan in vitro rilmenidine ke atas rembesan insulin. Jurnal Sains Kesihatan Malaysia, 1 . pp. 1-7. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal |
| spellingShingle | Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, Kesan in vitro rilmenidine ke atas rembesan insulin |
| title | Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_full | Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_fullStr | Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_full_unstemmed | Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_short | Kesan in vitro rilmenidine ke atas rembesan insulin |
| title_sort | kesan in vitro rilmenidine ke atas rembesan insulin |
| url | http://journalarticle.ukm.my/948/1/jurnal4.pdf http://journalarticle.ukm.my/948/ http://www.fskb.ukm.my/fskbold/jurnal |
| url_provider | http://journalarticle.ukm.my/ |