Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
This study was carried out to determine the potential of technetium-99m pertechnetate Human Immunoglobulin G (***Tc.HIgG) as a radiopharmaceutical agent in the detection of inflammation site. Reduced HLgG antibody was found to be stabled at the optimal storage temperatures of -70°C and 0°C and deter...
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| Format: | Article |
| Language: | en |
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penerbit ukm
2003
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| Online Access: | http://journalarticle.ukm.my/947/1/jurnal3.pdf http://journalarticle.ukm.my/947/ http://www.fskb.ukm.my/fskbold/jurnal |
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| author | Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid, |
| author_facet | Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid, |
| author_sort | Rosnani Hashim, |
| building | Tun Sri Lanang Library |
| collection | Institutional Repository |
| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | This study was carried out to determine the potential of technetium-99m pertechnetate Human Immunoglobulin G (***Tc.HIgG) as a radiopharmaceutical agent in the detection of inflammation site. Reduced HLgG antibody was found to be stabled at the optimal storage temperatures of -70°C and 0°C and deteriorated at 2 - N°C. The percentage of labeling of HIgG with ***Tc obtained was more than 95%. Biodistribution of ***Tc-HIgG was studied by using Sprague Dawley rats which were injected intramuscularly with turpentine to induce localized inflammation. The biodistribution of ***Tc-HIgG was determined by using immunosintigraphy (scanning) and kill and count method. Immunosintigram obtained after 4 hours post injection showed the clearest image of ***Tc-HIgG biodistribution in the inflamed muscle. The cut and count method also indicated that uptake of ***Tc-HIgG by the inflamed muscle was highest after 4 hours post injection. The pattern of ***Tc localization was different from ***Tc-HIgG. Imaging of inflamed cells using radiopharmaceutical ***Tc-HIgG, Possesses the potential to be used in the diagnosis of infection’inflammation such as in cancer or immunocompromised patients and in assessing patient’s response to the therapy of inflammatory diseases. |
| format | Article |
| id | my-ukm.journal-947 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2003 |
| publisher | penerbit ukm |
| record_format | eprints |
| spelling | my-ukm.journal-9472016-12-14T06:28:23Z http://journalarticle.ukm.my/947/ Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid, This study was carried out to determine the potential of technetium-99m pertechnetate Human Immunoglobulin G (***Tc.HIgG) as a radiopharmaceutical agent in the detection of inflammation site. Reduced HLgG antibody was found to be stabled at the optimal storage temperatures of -70°C and 0°C and deteriorated at 2 - N°C. The percentage of labeling of HIgG with ***Tc obtained was more than 95%. Biodistribution of ***Tc-HIgG was studied by using Sprague Dawley rats which were injected intramuscularly with turpentine to induce localized inflammation. The biodistribution of ***Tc-HIgG was determined by using immunosintigraphy (scanning) and kill and count method. Immunosintigram obtained after 4 hours post injection showed the clearest image of ***Tc-HIgG biodistribution in the inflamed muscle. The cut and count method also indicated that uptake of ***Tc-HIgG by the inflamed muscle was highest after 4 hours post injection. The pattern of ***Tc localization was different from ***Tc-HIgG. Imaging of inflamed cells using radiopharmaceutical ***Tc-HIgG, Possesses the potential to be used in the diagnosis of infection’inflammation such as in cancer or immunocompromised patients and in assessing patient’s response to the therapy of inflammatory diseases. penerbit ukm 2003-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/947/1/jurnal3.pdf Rosnani Hashim, and Shaharuddin Mohd, and Ang, Woan Tze and Wan Hamirul Bahrin Wan Kamal, and Shahrin Abdul Hamid, (2003) Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi. Jurnal Sains Kesihatan Malaysia, 1 . pp. 61-72. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal |
| spellingShingle | Rosnani Hashim, Shaharuddin Mohd, Ang, Woan Tze Wan Hamirul Bahrin Wan Kamal, Shahrin Abdul Hamid, Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi |
| title | Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi |
| title_full | Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi |
| title_fullStr | Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi |
| title_full_unstemmed | Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi |
| title_short | Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi |
| title_sort | teknetium-99 perteknetat imunoglobulin g manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi |
| url | http://journalarticle.ukm.my/947/1/jurnal3.pdf http://journalarticle.ukm.my/947/ http://www.fskb.ukm.my/fskbold/jurnal |
| url_provider | http://journalarticle.ukm.my/ |