Risk factors for candidaemia in a Malaysian tertiary hospital
Candidaemia carries high morbidity and mortality, but its conventional diagnosis is time consuming and insensitive. Clinical risk factors may identify suitable candidates for prophylactic or pre-emptive antifungal therapy and may be modified or controlled to prevent candidaemia. Therefore, this stud...
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Universiti Kebangsaan Malaysia
2015
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| Online Access: | http://journalarticle.ukm.my/8949/1/13_M.N._Tzar.pdf http://journalarticle.ukm.my/8949/ http://www.ukm.my/jsm/malay_journals/jilid44bil5_2015/KandunganJilid44Bil5_2015.html |
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| author | Tzar, M.N. Norazlah, B. Shamsul, A.S. |
| author_facet | Tzar, M.N. Norazlah, B. Shamsul, A.S. |
| author_sort | Tzar, M.N. |
| building | Tun Sri Lanang Library |
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| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Candidaemia carries high morbidity and mortality, but its conventional diagnosis is time consuming and insensitive. Clinical risk factors may identify suitable candidates for prophylactic or pre-emptive antifungal therapy and may be modified or controlled to prevent candidaemia. Therefore, this study aimed to identify the independent risk factors for candidaemia. The study was a retrospective, case-control study involving 54 patients with candidaemia and 54 patients without candidaemia as controls. The patient’s data were collected from the medical records and the risk factors for candidaemia were analyzed in both groups. Candida species isolated from blood were C. tropicalis (n=19, 35.2%), C. albicans (n=18, 33.3%), C. parapsilosis (n=11, 20.4%) and one isolate each (1.9%) of C. famata, C. glabrata, C. krusei, C. melibiosica, C. pelliculosa and C. sake. Multivariate analysis showed that renal insufficiency, prior antibacterial therapy, prior antifungal therapy, steroid therapy and urinary catheterization were independent risk factors for candidaemia. Central venous catheter, prolonged hospital stay, intensive care unit stay, mechanical ventilation, surgery and parenteral nutrition occurred more commonly among the candidaemia group but were not independently significant. Controlling, limiting or modifying these risk factors may reduce the incidence of candidaemia. |
| format | Article |
| id | my-ukm.journal-8949 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2015 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my-ukm.journal-89492016-12-14T06:48:31Z http://journalarticle.ukm.my/8949/ Risk factors for candidaemia in a Malaysian tertiary hospital Tzar, M.N. Norazlah, B. Shamsul, A.S. Candidaemia carries high morbidity and mortality, but its conventional diagnosis is time consuming and insensitive. Clinical risk factors may identify suitable candidates for prophylactic or pre-emptive antifungal therapy and may be modified or controlled to prevent candidaemia. Therefore, this study aimed to identify the independent risk factors for candidaemia. The study was a retrospective, case-control study involving 54 patients with candidaemia and 54 patients without candidaemia as controls. The patient’s data were collected from the medical records and the risk factors for candidaemia were analyzed in both groups. Candida species isolated from blood were C. tropicalis (n=19, 35.2%), C. albicans (n=18, 33.3%), C. parapsilosis (n=11, 20.4%) and one isolate each (1.9%) of C. famata, C. glabrata, C. krusei, C. melibiosica, C. pelliculosa and C. sake. Multivariate analysis showed that renal insufficiency, prior antibacterial therapy, prior antifungal therapy, steroid therapy and urinary catheterization were independent risk factors for candidaemia. Central venous catheter, prolonged hospital stay, intensive care unit stay, mechanical ventilation, surgery and parenteral nutrition occurred more commonly among the candidaemia group but were not independently significant. Controlling, limiting or modifying these risk factors may reduce the incidence of candidaemia. Universiti Kebangsaan Malaysia 2015-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/8949/1/13_M.N._Tzar.pdf Tzar, M.N. and Norazlah, B. and Shamsul, A.S. (2015) Risk factors for candidaemia in a Malaysian tertiary hospital. Sains Malaysiana, 44 (5). pp. 735-740. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid44bil5_2015/KandunganJilid44Bil5_2015.html |
| spellingShingle | Tzar, M.N. Norazlah, B. Shamsul, A.S. Risk factors for candidaemia in a Malaysian tertiary hospital |
| title | Risk factors for candidaemia in a Malaysian tertiary hospital |
| title_full | Risk factors for candidaemia in a Malaysian tertiary hospital |
| title_fullStr | Risk factors for candidaemia in a Malaysian tertiary hospital |
| title_full_unstemmed | Risk factors for candidaemia in a Malaysian tertiary hospital |
| title_short | Risk factors for candidaemia in a Malaysian tertiary hospital |
| title_sort | risk factors for candidaemia in a malaysian tertiary hospital |
| url | http://journalarticle.ukm.my/8949/1/13_M.N._Tzar.pdf http://journalarticle.ukm.my/8949/ http://www.ukm.my/jsm/malay_journals/jilid44bil5_2015/KandunganJilid44Bil5_2015.html |
| url_provider | http://journalarticle.ukm.my/ |