DNA repair at the gene level in trichothiodystrophy cells
Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a...
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Universiti Kebangsaan Malaysia
2000
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| Online Access: | http://journalarticle.ukm.my/3779/ http://www.ukm.my/jsm/english_journals/vol29_2000/vol29_00page19-31.html |
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| _version_ | 1831354973360750592 |
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| author | Nathan , Sheila Mayne, Lynne |
| author_facet | Nathan , Sheila Mayne, Lynne |
| author_sort | Nathan , Sheila |
| building | Tun Sri Lanang Library |
| collection | Institutional Repository |
| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of dimers at the gene-level. The results indicated a defect in gene-specific repair of dimers at early times post-irradiation due to the inability of the cells to repair dimers from the transcribed strand of the active gene. These findings indicate that TTD group 3 cells are unable to remove DNA lesions preferentially and this might contribute to other inherent symptoms of these patients. |
| format | Article |
| id | my-ukm.journal-3779 |
| institution | Universiti Kebangsaan Malaysia |
| publishDate | 2000 |
| publisher | Universiti Kebangsaan Malaysia |
| record_format | eprints |
| spelling | my-ukm.journal-37792012-03-20T01:56:29Z http://journalarticle.ukm.my/3779/ DNA repair at the gene level in trichothiodystrophy cells Nathan , Sheila Mayne, Lynne Cells from trichothiodystrophy (TTD) group 3 patients are non-hypersensitive to uv irradiation. These cells perform normal genome repair of pyrimidine dimers but fail to excise 6-4 photoproducts and concomitantly, are unable to restore RNA synthesis levels following uv irradiation. This pointed to a defect in gene-specific repair and this study was undertaken to examine repair of dimers at the gene-level. The results indicated a defect in gene-specific repair of dimers at early times post-irradiation due to the inability of the cells to repair dimers from the transcribed strand of the active gene. These findings indicate that TTD group 3 cells are unable to remove DNA lesions preferentially and this might contribute to other inherent symptoms of these patients. Universiti Kebangsaan Malaysia 2000 Article PeerReviewed Nathan , Sheila and Mayne, Lynne (2000) DNA repair at the gene level in trichothiodystrophy cells. Sains Malaysiana, 29 . pp. 19-31. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol29_2000/vol29_00page19-31.html |
| spellingShingle | Nathan , Sheila Mayne, Lynne DNA repair at the gene level in trichothiodystrophy cells |
| title | DNA repair at the gene level in trichothiodystrophy cells |
| title_full | DNA repair at the gene level in trichothiodystrophy cells |
| title_fullStr | DNA repair at the gene level in trichothiodystrophy cells |
| title_full_unstemmed | DNA repair at the gene level in trichothiodystrophy cells |
| title_short | DNA repair at the gene level in trichothiodystrophy cells |
| title_sort | dna repair at the gene level in trichothiodystrophy cells |
| url | http://journalarticle.ukm.my/3779/ http://www.ukm.my/jsm/english_journals/vol29_2000/vol29_00page19-31.html |
| url_provider | http://journalarticle.ukm.my/ |