Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report
Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasou...
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| Format: | Article |
| Language: | en |
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Penerbit UKM
2008
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| Online Access: | http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf http://journalarticle.ukm.my/2021/ http://www.ppukm.ukm.my/ukmmcjournal/index.php |
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| author | Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A, |
| author_facet | Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A, |
| author_sort | Siti-Aishah M.A., |
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| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3%
of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph
nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in
the left iliac fossa region. Ultrasound findings showed a well defined inhomogenous soft
tissue mass, measuring 4x4x2.6cm in the deep subcutaneous region. Histopathological
examination revealed that the mass was infiltrated by large lymphoid cells with marked
nuclear atypia including kidney-shaped nuclei. These neoplastic cells expressed anaplastic lymphoma kinase (ALK) (both nuclear & cytoplasmic staining), CD30 and EMA but not for
T-cell (CD45RO and CD3), and B-cell (CD20 & CD79α) markers. Fluorescence in situ
hybridization (FISH) analysis showed a t(2;5)(p23;q35) chromosomal translocation.
Subsequently the patient developed shortness of the breath and a thoracic computed
tomography (CT) scan showed a mass encasing the right upper lobe bronchus. She also
had bilateral axillary lymph nodes, measuring 1 cm in diameter (biopsy was not done). The
mediastinum and endobronchial region did not show any abnormalities. She received 6
cycles of CHOP chemotherapy and remained disease free 2 years after diagnosis. ALCL,
rarely present as a soft tissue tumour and this disease should be included as a differential
diagnosis of any soft tissue mass |
| format | Article |
| id | my-ukm.journal-2021 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2008 |
| publisher | Penerbit UKM |
| record_format | eprints |
| spelling | my-ukm.journal-20212016-12-14T06:30:41Z http://journalarticle.ukm.my/2021/ Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A, Anaplastic large cell lymphoma (ALCL) is a rare tumour, accounting for approximately 3% of adult non-Hodgkin lymphomas.1 Primary systemic ALCL frequently involves both lymph nodes and extranodal sites. A 44-year-old woman presented with a firm, mobile mass in the left iliac fossa region. Ultrasound findings showed a well defined inhomogenous soft tissue mass, measuring 4x4x2.6cm in the deep subcutaneous region. Histopathological examination revealed that the mass was infiltrated by large lymphoid cells with marked nuclear atypia including kidney-shaped nuclei. These neoplastic cells expressed anaplastic lymphoma kinase (ALK) (both nuclear & cytoplasmic staining), CD30 and EMA but not for T-cell (CD45RO and CD3), and B-cell (CD20 & CD79α) markers. Fluorescence in situ hybridization (FISH) analysis showed a t(2;5)(p23;q35) chromosomal translocation. Subsequently the patient developed shortness of the breath and a thoracic computed tomography (CT) scan showed a mass encasing the right upper lobe bronchus. She also had bilateral axillary lymph nodes, measuring 1 cm in diameter (biopsy was not done). The mediastinum and endobronchial region did not show any abnormalities. She received 6 cycles of CHOP chemotherapy and remained disease free 2 years after diagnosis. ALCL, rarely present as a soft tissue tumour and this disease should be included as a differential diagnosis of any soft tissue mass Penerbit UKM 2008 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf Siti-Aishah M.A., and Salwati S,, and Idrus M., and Rahimah R., and Salmi A., and Leong C.F., and Sharifah N.A, (2008) Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report. Medicine & Health, 3 (1). pp. 69-74. ISSN 1823-2140 http://www.ppukm.ukm.my/ukmmcjournal/index.php |
| spellingShingle | Siti-Aishah M.A., Salwati S,, Idrus M., Rahimah R., Salmi A., Leong C.F., Sharifah N.A, Anaplastic large cell lymphoma presenting as a soft tissue mass – A case report |
| title | Anaplastic large cell lymphoma presenting as a soft
tissue mass – A case report |
| title_full | Anaplastic large cell lymphoma presenting as a soft
tissue mass – A case report |
| title_fullStr | Anaplastic large cell lymphoma presenting as a soft
tissue mass – A case report |
| title_full_unstemmed | Anaplastic large cell lymphoma presenting as a soft
tissue mass – A case report |
| title_short | Anaplastic large cell lymphoma presenting as a soft
tissue mass – A case report |
| title_sort | anaplastic large cell lymphoma presenting as a soft
tissue mass – a case report |
| url | http://journalarticle.ukm.my/2021/1/Page_69_-_74.pdf http://journalarticle.ukm.my/2021/ http://www.ppukm.ukm.my/ukmmcjournal/index.php |
| url_provider | http://journalarticle.ukm.my/ |