Bleeding risk factors with enoxaparin for patients with NSTEMI/UA in HUKM
Low-molecular-weight heparins (LMWHs) are antithrombotic agents utilised in the treatment of acute coronary syndromes. They have been shown to be more effective than unfractionated heparins (UFHs) in reducing ischeamic e v e n t s , w h i c h i n c l u d e d e a t h , my o c a r d i a l...
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| Language: | en |
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Penerbit UKM
2008
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| Online Access: | http://journalarticle.ukm.my/1401/1/Noraida%20Mohamed%20Shah%20et%20al..pdf http://journalarticle.ukm.my/1401/ http://www.fskb.ukm.my/fskbold/jurnal.html |
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| author | Noraida Mohamed Shah, Rosnani Hashim, Azmi Sarriff, |
| author_facet | Noraida Mohamed Shah, Rosnani Hashim, Azmi Sarriff, |
| author_sort | Noraida Mohamed Shah, |
| building | Tun Sri Lanang Library |
| collection | Institutional Repository |
| content_provider | Universiti Kebangsaan Malaysia |
| content_source | UKM Journal Article Repository |
| continent | Asia |
| country | Malaysia |
| description | Low-molecular-weight heparins (LMWHs) are antithrombotic agents utilised
in the treatment of acute coronary syndromes. They have been shown to be
more effective than unfractionated heparins (UFHs) in reducing ischeamic
e v e n t s , w h i c h i n c l u d e d e a t h , my o c a r d i a l i n f a r c t i o n (MI) a n d u r g e n t
revascularisation. Enoxaparin is one of the products of LMWHs. Its safety and
efficacy has been proven in the ESSENCE and TIMI IIB studies. This study was
carried out to identify risk factors that may affect bleeding complications
associated with the use of enoxaparin for non-ST-elevation MI (NSTEMI) or
unstable angina (UA) in Universiti Kebangsaan Malaysia Hospital (HUKM).
This observational, longitudinal study was conducted on patients who were
admitted to the Coronary Care Unit (CCU), Coronary Rehabilitation Ward
(CRW), Medical 1 and Medical 2 wards at HUKM and initiated on enoxaparin
for NSTEMI/UA from 22
nd
of March until 22
nd
of April 2004. A total of 40 patients
were included in the study with median age of 65 years, male to female ratio of
3:1, diagnosed with NSTEMI (55%) and UA (45%). 45% of patients developed
an episode of bleeding and among them 83.3% (15 patients) characterised by
haematuria. Higher percentages of women (80%) and those with creatinine
clearance of < 30ml/min (100%) had incidence of bleeding as compared to
men (50%) and those with creatinine clearance ≥ 30 ml/min, respectively (p <
0.05 for both parameters). Age, enoxaparin dose and duration of therapy,
smoking and concomitant aspirin/ticlopidine therapy did not significantly
affect the incidence of bleeding. In conclusion, renal impairment and gender
were associated with bleeding in relation with the use of enoxaparin that may
require dose adjustments. |
| format | Article |
| id | my-ukm.journal-1401 |
| institution | Universiti Kebangsaan Malaysia |
| language | en |
| publishDate | 2008 |
| publisher | Penerbit UKM |
| record_format | eprints |
| spelling | my-ukm.journal-14012016-12-14T06:29:24Z http://journalarticle.ukm.my/1401/ Bleeding risk factors with enoxaparin for patients with NSTEMI/UA in HUKM Noraida Mohamed Shah, Rosnani Hashim, Azmi Sarriff, Low-molecular-weight heparins (LMWHs) are antithrombotic agents utilised in the treatment of acute coronary syndromes. They have been shown to be more effective than unfractionated heparins (UFHs) in reducing ischeamic e v e n t s , w h i c h i n c l u d e d e a t h , my o c a r d i a l i n f a r c t i o n (MI) a n d u r g e n t revascularisation. Enoxaparin is one of the products of LMWHs. Its safety and efficacy has been proven in the ESSENCE and TIMI IIB studies. This study was carried out to identify risk factors that may affect bleeding complications associated with the use of enoxaparin for non-ST-elevation MI (NSTEMI) or unstable angina (UA) in Universiti Kebangsaan Malaysia Hospital (HUKM). This observational, longitudinal study was conducted on patients who were admitted to the Coronary Care Unit (CCU), Coronary Rehabilitation Ward (CRW), Medical 1 and Medical 2 wards at HUKM and initiated on enoxaparin for NSTEMI/UA from 22 nd of March until 22 nd of April 2004. A total of 40 patients were included in the study with median age of 65 years, male to female ratio of 3:1, diagnosed with NSTEMI (55%) and UA (45%). 45% of patients developed an episode of bleeding and among them 83.3% (15 patients) characterised by haematuria. Higher percentages of women (80%) and those with creatinine clearance of < 30ml/min (100%) had incidence of bleeding as compared to men (50%) and those with creatinine clearance ≥ 30 ml/min, respectively (p < 0.05 for both parameters). Age, enoxaparin dose and duration of therapy, smoking and concomitant aspirin/ticlopidine therapy did not significantly affect the incidence of bleeding. In conclusion, renal impairment and gender were associated with bleeding in relation with the use of enoxaparin that may require dose adjustments. Penerbit UKM 2008-06 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/1401/1/Noraida%20Mohamed%20Shah%20et%20al..pdf Noraida Mohamed Shah, and Rosnani Hashim, and Azmi Sarriff, (2008) Bleeding risk factors with enoxaparin for patients with NSTEMI/UA in HUKM. Jurnal Sains Kesihatan Malaysia, 6 (1). pp. 23-34. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal.html |
| spellingShingle | Noraida Mohamed Shah, Rosnani Hashim, Azmi Sarriff, Bleeding risk factors with enoxaparin for patients with NSTEMI/UA in HUKM |
| title | Bleeding risk factors with enoxaparin for patients
with NSTEMI/UA in HUKM |
| title_full | Bleeding risk factors with enoxaparin for patients
with NSTEMI/UA in HUKM |
| title_fullStr | Bleeding risk factors with enoxaparin for patients
with NSTEMI/UA in HUKM |
| title_full_unstemmed | Bleeding risk factors with enoxaparin for patients
with NSTEMI/UA in HUKM |
| title_short | Bleeding risk factors with enoxaparin for patients
with NSTEMI/UA in HUKM |
| title_sort | bleeding risk factors with enoxaparin for patients
with nstemi/ua in hukm |
| url | http://journalarticle.ukm.my/1401/1/Noraida%20Mohamed%20Shah%20et%20al..pdf http://journalarticle.ukm.my/1401/ http://www.fskb.ukm.my/fskbold/jurnal.html |
| url_provider | http://journalarticle.ukm.my/ |