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Study on sentinel hosts for surveillance of future COVID-19-like outbreaks

The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhu...

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Main Authors: Li, Yanjiao, Hu, Jingjing, Hou, Jingjing, Lu, Shuiping, Xiong, Jiasheng, Wang, Yuxi, Sun, Zhong, Chen, Weijie, Pan, Yue, Thilakavathy, Karuppiah, Feng, Yi, Jiang, Qingwu, Wang, Weibing, Xiong, Chenglong
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2024
Online Access:http://psasir.upm.edu.my/id/eprint/115241/1/115241.pdf
http://psasir.upm.edu.my/id/eprint/115241/
https://www.nature.com/articles/s41598-024-76506-7?error=cookies_not_supported&code=9c4338ff-0201-469f-8b9b-7e6ec6f99414
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spelling my.upm.eprints.1152412025-02-26T08:31:01Z http://psasir.upm.edu.my/id/eprint/115241/ Study on sentinel hosts for surveillance of future COVID-19-like outbreaks Li, Yanjiao Hu, Jingjing Hou, Jingjing Lu, Shuiping Xiong, Jiasheng Wang, Yuxi Sun, Zhong Chen, Weijie Pan, Yue Thilakavathy, Karuppiah Feng, Yi Jiang, Qingwu Wang, Weibing Xiong, Chenglong The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants. Springer Science and Business Media LLC 2024 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/115241/1/115241.pdf Li, Yanjiao and Hu, Jingjing and Hou, Jingjing and Lu, Shuiping and Xiong, Jiasheng and Wang, Yuxi and Sun, Zhong and Chen, Weijie and Pan, Yue and Thilakavathy, Karuppiah and Feng, Yi and Jiang, Qingwu and Wang, Weibing and Xiong, Chenglong (2024) Study on sentinel hosts for surveillance of future COVID-19-like outbreaks. Scientific Reports, 14 (1). art. no. 24595. pp. 1-11. ISSN 2045-2322 https://www.nature.com/articles/s41598-024-76506-7?error=cookies_not_supported&code=9c4338ff-0201-469f-8b9b-7e6ec6f99414 10.1038/s41598-024-76506-7
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description The spread of SARS-CoV-2 to animals has the potential to evolve independently. In this study, we distinguished several sentinel animal species and genera for monitoring the re-emergence of COVID-19 or the new outbreak of COVID-19-like disease. We analyzed SARS-CoV-2 genomic data from human and nonhuman mammals in the taxonomic hierarchies of species, genus, family and order of their host. We find that SARS-CoV-2 carried by domestic dog (Canis lupus familiaris), domestic cat (Felis catus), mink (Neovison vison), and white-tailed deer (Odocoileus virginianus) cluster closely to human-origin viruses and show no differences in the majority of amino acids, but have the most positively selected sites and should be monitored to prevent the re-emergence of COVID-19 caused by novel variants of SARS-CoV-2. Viruses from the genera Panthera (especially lion (Panthera leo)), Manis and Rhinolophus differ significantly from human-origin viruses, and long-term surveillance should be undertaken to prevent the future COVID-19-like outbreaks. Investigation of the variation dynamics of sites 142, 501, 655, 681 and 950 within the S protein may be necessary to predict the novel animal SARS-CoV-2 variants.
format Article
author Li, Yanjiao
Hu, Jingjing
Hou, Jingjing
Lu, Shuiping
Xiong, Jiasheng
Wang, Yuxi
Sun, Zhong
Chen, Weijie
Pan, Yue
Thilakavathy, Karuppiah
Feng, Yi
Jiang, Qingwu
Wang, Weibing
Xiong, Chenglong
spellingShingle Li, Yanjiao
Hu, Jingjing
Hou, Jingjing
Lu, Shuiping
Xiong, Jiasheng
Wang, Yuxi
Sun, Zhong
Chen, Weijie
Pan, Yue
Thilakavathy, Karuppiah
Feng, Yi
Jiang, Qingwu
Wang, Weibing
Xiong, Chenglong
Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
author_facet Li, Yanjiao
Hu, Jingjing
Hou, Jingjing
Lu, Shuiping
Xiong, Jiasheng
Wang, Yuxi
Sun, Zhong
Chen, Weijie
Pan, Yue
Thilakavathy, Karuppiah
Feng, Yi
Jiang, Qingwu
Wang, Weibing
Xiong, Chenglong
author_sort Li, Yanjiao
title Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
title_short Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
title_full Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
title_fullStr Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
title_full_unstemmed Study on sentinel hosts for surveillance of future COVID-19-like outbreaks
title_sort study on sentinel hosts for surveillance of future covid-19-like outbreaks
publisher Springer Science and Business Media LLC
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/115241/1/115241.pdf
http://psasir.upm.edu.my/id/eprint/115241/
https://www.nature.com/articles/s41598-024-76506-7?error=cookies_not_supported&code=9c4338ff-0201-469f-8b9b-7e6ec6f99414
_version_ 1825162455381180416
score 13.239859

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