Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer
Colorectal cancer (CRC) is one of the main causes of cancer‐related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer‐related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regen...
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John Wiley and Sons Ltd
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/114978/ https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cbf.3962 |
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my.upm.eprints.1149782025-02-13T05:03:12Z http://psasir.upm.edu.my/id/eprint/114978/ Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer Saadh, Mohamed J. Mohamed, Asma'a H. Almoyad, Muhammad Ali Abdullah Allela, Omer Qutaiba B. Amin, Ali H. Malquisto, April Ann Wong, Tze Jin Sârbu, Ioan AlShamsi, Faisal Elsaid, Fahmy Gad Akhavan-Sigari, Reza Colorectal cancer (CRC) is one of the main causes of cancer‐related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer‐related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through secreting exosomes. The beneficial properties of stem cells are attributed to their cell–cell interactions as well as the secretion of paracrine factors in the tissue microenvironment. For several years, exosomes have been used as a cell‐free therapy to regulate the fate of tumor cells in a tumor microenvironment. This review discusses the recent advances and current understanding of assessing MSC‐derived exosomes for possible cell‐free therapy in CRC. John Wiley and Sons Ltd 2024-03 Article PeerReviewed Saadh, Mohamed J. and Mohamed, Asma'a H. and Almoyad, Muhammad Ali Abdullah and Allela, Omer Qutaiba B. and Amin, Ali H. and Malquisto, April Ann and Wong, Tze Jin and Sârbu, Ioan and AlShamsi, Faisal and Elsaid, Fahmy Gad and Akhavan-Sigari, Reza (2024) Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer. Cell Biochemistry and Function, 42 (2). art. no. e3962. ISSN 0263-6484; eISSN: 1099-0844 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cbf.3962 10.1002/cbf.3962 |
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Colorectal cancer (CRC) is one of the main causes of cancer‐related deaths. However, the surgical control of the CRC progression is difficult, and in most cases, the metastasis leads to cancer‐related mortality. Mesenchymal stem/stromal cells (MSCs) with potential translational applications in regenerative medicine have been widely researched for several years. MSCs could affect tumor development through secreting exosomes. The beneficial properties of stem cells are attributed to their cell–cell interactions as well as the secretion of paracrine factors in the tissue microenvironment. For several years, exosomes have been used as a cell‐free therapy to regulate the fate of tumor cells in a tumor microenvironment. This review discusses the recent advances and current understanding of assessing MSC‐derived exosomes for possible cell‐free therapy in CRC. |
| format |
Article |
| author |
Saadh, Mohamed J. Mohamed, Asma'a H. Almoyad, Muhammad Ali Abdullah Allela, Omer Qutaiba B. Amin, Ali H. Malquisto, April Ann Wong, Tze Jin Sârbu, Ioan AlShamsi, Faisal Elsaid, Fahmy Gad Akhavan-Sigari, Reza |
| spellingShingle |
Saadh, Mohamed J. Mohamed, Asma'a H. Almoyad, Muhammad Ali Abdullah Allela, Omer Qutaiba B. Amin, Ali H. Malquisto, April Ann Wong, Tze Jin Sârbu, Ioan AlShamsi, Faisal Elsaid, Fahmy Gad Akhavan-Sigari, Reza Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer |
| author_facet |
Saadh, Mohamed J. Mohamed, Asma'a H. Almoyad, Muhammad Ali Abdullah Allela, Omer Qutaiba B. Amin, Ali H. Malquisto, April Ann Wong, Tze Jin Sârbu, Ioan AlShamsi, Faisal Elsaid, Fahmy Gad Akhavan-Sigari, Reza |
| author_sort |
Saadh, Mohamed J. |
| title |
Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer |
| title_short |
Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer |
| title_full |
Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer |
| title_fullStr |
Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer |
| title_full_unstemmed |
Dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer |
| title_sort |
dual role of mesenchymal stem/stromal cells and their cell‐free extracellular vesicles in colorectal cancer |
| publisher |
John Wiley and Sons Ltd |
| publishDate |
2024 |
| url |
http://psasir.upm.edu.my/id/eprint/114978/ https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/cbf.3962 |
| _version_ |
1825162408600010752 |
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13.239859 |