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Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical

In an era where synthetic supplements have raised concerns regarding their effects on human health, Ficus carica has emerged as a natural alternative rich in polyphenolic compounds with potent therapeutic properties. Various studies on F. carica focusing on the analysis and validation of its pharmac...

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Main Authors:	Abu, Izuddin Fahmy, Fazel, Muhammad Fattah, Mohamad, Mohamad Haiqal Nizar, Daud, Noor Arniwati Mat, Hasan, Ahmad Najib, Bakkar, Zainie Aboo, Khir, Muhammad Alif Naim Md, Juliana, Norsham, Das, Srijit, Razali, Muhamad Razin Mohd, Baharin, Nurul Hana Zainal, Ismail, Arashidatul Akmar
Format:	Article
Published:	Dove Medical Press 2024
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://eprints.um.edu.my/47065/ https://doi.org/10.2147/DDDT.S436446
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spelling	my.um.eprints.470652025-01-06T01:15:44Z http://eprints.um.edu.my/47065/ Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical Abu, Izuddin Fahmy Fazel, Muhammad Fattah Mohamad, Mohamad Haiqal Nizar Daud, Noor Arniwati Mat Hasan, Ahmad Najib Bakkar, Zainie Aboo Khir, Muhammad Alif Naim Md Juliana, Norsham Das, Srijit Razali, Muhamad Razin Mohd Baharin, Nurul Hana Zainal Ismail, Arashidatul Akmar RM Therapeutics. Pharmacology RS Pharmacy and materia medica In an era where synthetic supplements have raised concerns regarding their effects on human health, Ficus carica has emerged as a natural alternative rich in polyphenolic compounds with potent therapeutic properties. Various studies on F. carica focusing on the analysis and validation of its pharmacological and nutritional properties are emerging. This paper summarizes present data and information on the phytochemical, nutritional values, therapeutic potential, as well as the toxicity profile of F. carica . An extensive search was conducted from various databases, including PubMed, ScienceDirect, Scopus, and Google Scholar. A total of 126 studies and articles related to F. carica that were published between 1999 and 2023 were included in this review. Remarkably, F. carica exhibits a diverse array of advantageous effects, including, but not limited to, antioxidant, anti-neurodegenerative, antimicrobial, antiviral, anti-inflammatory, anti-arthritic, antiepileptic, anticonvulsant, anti-hyperlipidemic, anti-angiogenic, antidiabetic, anti -cancer, and antimutagenic properties. Among the highlights include that antioxidants from F. carica were demonstrated to inhibit cholinesterase, potentially protecting neurons in Alzheimer's disease and other neurodegenerative conditions. The antimicrobial activities of F. carica were attributed to its high flavonoids and terpenoids content, while its virucidal action through the inhibition of DNA and RNA replication was postulated due to its triterpenes content. Inflammatory and arthritic conditions may also benefit from its anti-inflammatory and anti-arthritic properties through the modulation of various signalling proteins. Studies have also shown that F. carica extracts were generally safe and exhibit low toxicity profile, although more research in this aspect is required, specifically its effects on the skin. In conclusion, this study highlights the potential of F. carica as a valuable natural therapeutic agent and dietary supplement. However, continued exploration on F. carica' s safety and efficacy is still required prior to embarking on clinical trials, as its role in personalized nutrition and medication will open a new paradigm to improve health outcomes. Dove Medical Press 2024 Article PeerReviewed Abu, Izuddin Fahmy and Fazel, Muhammad Fattah and Mohamad, Mohamad Haiqal Nizar and Daud, Noor Arniwati Mat and Hasan, Ahmad Najib and Bakkar, Zainie Aboo and Khir, Muhammad Alif Naim Md and Juliana, Norsham and Das, Srijit and Razali, Muhamad Razin Mohd and Baharin, Nurul Hana Zainal and Ismail, Arashidatul Akmar (2024) Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical. Drug Design, Development and Therapy, 18. pp. 1947-1968. ISSN 1177-8881, DOI https://doi.org/10.2147/DDDT.S436446 <https://doi.org/10.2147/DDDT.S436446>. https://doi.org/10.2147/DDDT.S436446 10.2147/DDDT.S436446
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Abu, Izuddin Fahmy Fazel, Muhammad Fattah Mohamad, Mohamad Haiqal Nizar Daud, Noor Arniwati Mat Hasan, Ahmad Najib Bakkar, Zainie Aboo Khir, Muhammad Alif Naim Md Juliana, Norsham Das, Srijit Razali, Muhamad Razin Mohd Baharin, Nurul Hana Zainal Ismail, Arashidatul Akmar Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical
description	In an era where synthetic supplements have raised concerns regarding their effects on human health, Ficus carica has emerged as a natural alternative rich in polyphenolic compounds with potent therapeutic properties. Various studies on F. carica focusing on the analysis and validation of its pharmacological and nutritional properties are emerging. This paper summarizes present data and information on the phytochemical, nutritional values, therapeutic potential, as well as the toxicity profile of F. carica . An extensive search was conducted from various databases, including PubMed, ScienceDirect, Scopus, and Google Scholar. A total of 126 studies and articles related to F. carica that were published between 1999 and 2023 were included in this review. Remarkably, F. carica exhibits a diverse array of advantageous effects, including, but not limited to, antioxidant, anti-neurodegenerative, antimicrobial, antiviral, anti-inflammatory, anti-arthritic, antiepileptic, anticonvulsant, anti-hyperlipidemic, anti-angiogenic, antidiabetic, anti -cancer, and antimutagenic properties. Among the highlights include that antioxidants from F. carica were demonstrated to inhibit cholinesterase, potentially protecting neurons in Alzheimer's disease and other neurodegenerative conditions. The antimicrobial activities of F. carica were attributed to its high flavonoids and terpenoids content, while its virucidal action through the inhibition of DNA and RNA replication was postulated due to its triterpenes content. Inflammatory and arthritic conditions may also benefit from its anti-inflammatory and anti-arthritic properties through the modulation of various signalling proteins. Studies have also shown that F. carica extracts were generally safe and exhibit low toxicity profile, although more research in this aspect is required, specifically its effects on the skin. In conclusion, this study highlights the potential of F. carica as a valuable natural therapeutic agent and dietary supplement. However, continued exploration on F. carica' s safety and efficacy is still required prior to embarking on clinical trials, as its role in personalized nutrition and medication will open a new paradigm to improve health outcomes.
format	Article
author	Abu, Izuddin Fahmy Fazel, Muhammad Fattah Mohamad, Mohamad Haiqal Nizar Daud, Noor Arniwati Mat Hasan, Ahmad Najib Bakkar, Zainie Aboo Khir, Muhammad Alif Naim Md Juliana, Norsham Das, Srijit Razali, Muhamad Razin Mohd Baharin, Nurul Hana Zainal Ismail, Arashidatul Akmar
author_facet	Abu, Izuddin Fahmy Fazel, Muhammad Fattah Mohamad, Mohamad Haiqal Nizar Daud, Noor Arniwati Mat Hasan, Ahmad Najib Bakkar, Zainie Aboo Khir, Muhammad Alif Naim Md Juliana, Norsham Das, Srijit Razali, Muhamad Razin Mohd Baharin, Nurul Hana Zainal Ismail, Arashidatul Akmar
author_sort	Abu, Izuddin Fahmy
title	Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical
title_short	Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical
title_full	Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical
title_fullStr	Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical
title_full_unstemmed	Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical
title_sort	physicochemistry, nutritional, and therapeutic potential of ficus carica - a promising nutraceutical
publisher	Dove Medical Press
publishDate	2024
url	http://eprints.um.edu.my/47065/ https://doi.org/10.2147/DDDT.S436446
_version_	1821001883232239616
score	13.239243

Physicochemistry, Nutritional, and Therapeutic Potential of Ficus carica - A Promising Nutraceutical

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