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Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review

Colorectal cancer (CRC) continues to be one of the most prevalent and deadliest forms of cancer worldwide, despite notable advancements in its management. The prognosis for metastatic CRC remains discouraging, with a relative 5 -year survival rate for stage IV CRC patients. Conventional treatments f...

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Main Authors: Ibrahim, Intan Shazleen, Chellathurai, Melbha Starlin, Mahmood, Syed, Azmi, Amirul Hakim, Harun, Norsyifa, Nazri, Mohd Ulul Ilmie Ahmad, Mahat, Mohd Muzamir, Sofian, Zarif Mohamed
Format: Article
Published: Elsevier 2024
Subjects:
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/45813/
https://doi.org/10.1016/j.ijpharm.2023.123735
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spelling my.um.eprints.458132024-11-12T05:35:51Z http://eprints.um.edu.my/45813/ Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review Ibrahim, Intan Shazleen Chellathurai, Melbha Starlin Mahmood, Syed Azmi, Amirul Hakim Harun, Norsyifa Nazri, Mohd Ulul Ilmie Ahmad Mahat, Mohd Muzamir Sofian, Zarif Mohamed RM Therapeutics. Pharmacology RS Pharmacy and materia medica Colorectal cancer (CRC) continues to be one of the most prevalent and deadliest forms of cancer worldwide, despite notable advancements in its management. The prognosis for metastatic CRC remains discouraging, with a relative 5 -year survival rate for stage IV CRC patients. Conventional treatments for advanced malignancies such as chemotherapy, often face limitations in effectively targeting cancer cells resulting in off -target distribution and significant side effects. In the quest for better strategies, researchers have explored numerous alternatives. Among these, nanoparticles (NPs) specifically liposomes have emerged as one of the most promising candidates in developing targeted delivery systems for cancer therapeutics. This review discusses the current approaches employing functionalised liposomes to overcome major biological barriers in therapeutics delivery for CRC treatment. We have also shared our perspectives on the technological development of liposomes for future clinical use and highlighted a few useful insights on the material choices for future research work in CRC. Elsevier 2024-02 Article PeerReviewed Ibrahim, Intan Shazleen and Chellathurai, Melbha Starlin and Mahmood, Syed and Azmi, Amirul Hakim and Harun, Norsyifa and Nazri, Mohd Ulul Ilmie Ahmad and Mahat, Mohd Muzamir and Sofian, Zarif Mohamed (2024) Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review. International Journal of Pharmaceutics, 651. p. 123735. ISSN 0378-5173, DOI https://doi.org/10.1016/j.ijpharm.2023.123735 <https://doi.org/10.1016/j.ijpharm.2023.123735>. https://doi.org/10.1016/j.ijpharm.2023.123735 10.1016/j.ijpharm.2023.123735
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
spellingShingle RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Ibrahim, Intan Shazleen
Chellathurai, Melbha Starlin
Mahmood, Syed
Azmi, Amirul Hakim
Harun, Norsyifa
Nazri, Mohd Ulul Ilmie Ahmad
Mahat, Mohd Muzamir
Sofian, Zarif Mohamed
Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review
description Colorectal cancer (CRC) continues to be one of the most prevalent and deadliest forms of cancer worldwide, despite notable advancements in its management. The prognosis for metastatic CRC remains discouraging, with a relative 5 -year survival rate for stage IV CRC patients. Conventional treatments for advanced malignancies such as chemotherapy, often face limitations in effectively targeting cancer cells resulting in off -target distribution and significant side effects. In the quest for better strategies, researchers have explored numerous alternatives. Among these, nanoparticles (NPs) specifically liposomes have emerged as one of the most promising candidates in developing targeted delivery systems for cancer therapeutics. This review discusses the current approaches employing functionalised liposomes to overcome major biological barriers in therapeutics delivery for CRC treatment. We have also shared our perspectives on the technological development of liposomes for future clinical use and highlighted a few useful insights on the material choices for future research work in CRC.
format Article
author Ibrahim, Intan Shazleen
Chellathurai, Melbha Starlin
Mahmood, Syed
Azmi, Amirul Hakim
Harun, Norsyifa
Nazri, Mohd Ulul Ilmie Ahmad
Mahat, Mohd Muzamir
Sofian, Zarif Mohamed
author_facet Ibrahim, Intan Shazleen
Chellathurai, Melbha Starlin
Mahmood, Syed
Azmi, Amirul Hakim
Harun, Norsyifa
Nazri, Mohd Ulul Ilmie Ahmad
Mahat, Mohd Muzamir
Sofian, Zarif Mohamed
author_sort Ibrahim, Intan Shazleen
title Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review
title_short Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review
title_full Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review
title_fullStr Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review
title_full_unstemmed Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review
title_sort engineered liposomes mediated approach for targeted colorectal cancer drug delivery: a review
publisher Elsevier
publishDate 2024
url http://eprints.um.edu.my/45813/
https://doi.org/10.1016/j.ijpharm.2023.123735
_version_ 1816130463389974528
score 13.239237

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