Staff View: Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation

Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation

Sunflower oil, a commonly available vegetable oil, is used as a lipid component in nanoemulsion. When a nanoemulsion is loaded into an aqueous gel platform for transdermal delivery, skin permeation of a drug depends on the release of nanosize droplets from the gel. Semisolid characteristics, such as...

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Main Authors:	Ali, E. M. H., Mahmood, S., Sengupta, P., Doolaanea, A. A., Chatterjee, B.
Format:	Article
Published:	Indian Pharmaceutical Assoc 2023
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
Online Access:	http://eprints.um.edu.my/38478/
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spelling	my.um.eprints.384782024-11-27T03:28:04Z http://eprints.um.edu.my/38478/ Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation Ali, E. M. H. Mahmood, S. Sengupta, P. Doolaanea, A. A. Chatterjee, B. RM Therapeutics. Pharmacology RS Pharmacy and materia medica Sunflower oil, a commonly available vegetable oil, is used as a lipid component in nanoemulsion. When a nanoemulsion is loaded into an aqueous gel platform for transdermal delivery, skin permeation of a drug depends on the release of nanosize droplets from the gel. Semisolid characteristics, such as viscosity, spreadability, rheological properties, can greatly affect the drug release and permeation. We have formulated a nanoemulsion using sunflower oil as lipid carrier and raloxifene as a model drug by cold emulsification method. The most suitable nanoemulsion was composed of lipid:mixture of surfactant-cosurfactant (Tween 20-Transcutol (R) P, 3:1 w/w) in a ratio of 12.5:87.5 %. This formulation was loaded into carbopol 940 based gel in various ratios. Mechanical evaluation of the most suitable nanoemulgel (nanoemulsion: carbopol, 1:1 weight ratio) resulted in 94.0 +/- 4.62 g of hardness and 4.99 +/- 0.057 cm of spreadability. Shear-thinning and pseudoplastic behavior were evidenced in rheological evaluation. Ex vivo skin permeation study on rat skin showed a significant increase in the cumulative amount of drug permeation and steady-state permeation flux compared to the conventional gel. Increasing carbopol concentration showed increased viscosity and reduction in ex vivo drug permeation. The permeation enhancing effect of sunflower oil and Tween 20, nanosize droplets and enhanced retention of the dosage form over skin cumulatively increase the ex vivo drug permeation. Alternately, the potential of raloxifene transdermal delivery by sunflower oil-based nanoemulsion can be established. Indian Pharmaceutical Assoc 2023-03 Article PeerReviewed Ali, E. M. H. and Mahmood, S. and Sengupta, P. and Doolaanea, A. A. and Chatterjee, B. (2023) Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation. Indian Journal of Pharmaceutical Sciences, 85 (2). pp. 388-402. ISSN 0250-474X,
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Ali, E. M. H. Mahmood, S. Sengupta, P. Doolaanea, A. A. Chatterjee, B. Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation
description	Sunflower oil, a commonly available vegetable oil, is used as a lipid component in nanoemulsion. When a nanoemulsion is loaded into an aqueous gel platform for transdermal delivery, skin permeation of a drug depends on the release of nanosize droplets from the gel. Semisolid characteristics, such as viscosity, spreadability, rheological properties, can greatly affect the drug release and permeation. We have formulated a nanoemulsion using sunflower oil as lipid carrier and raloxifene as a model drug by cold emulsification method. The most suitable nanoemulsion was composed of lipid:mixture of surfactant-cosurfactant (Tween 20-Transcutol (R) P, 3:1 w/w) in a ratio of 12.5:87.5 %. This formulation was loaded into carbopol 940 based gel in various ratios. Mechanical evaluation of the most suitable nanoemulgel (nanoemulsion: carbopol, 1:1 weight ratio) resulted in 94.0 +/- 4.62 g of hardness and 4.99 +/- 0.057 cm of spreadability. Shear-thinning and pseudoplastic behavior were evidenced in rheological evaluation. Ex vivo skin permeation study on rat skin showed a significant increase in the cumulative amount of drug permeation and steady-state permeation flux compared to the conventional gel. Increasing carbopol concentration showed increased viscosity and reduction in ex vivo drug permeation. The permeation enhancing effect of sunflower oil and Tween 20, nanosize droplets and enhanced retention of the dosage form over skin cumulatively increase the ex vivo drug permeation. Alternately, the potential of raloxifene transdermal delivery by sunflower oil-based nanoemulsion can be established.
format	Article
author	Ali, E. M. H. Mahmood, S. Sengupta, P. Doolaanea, A. A. Chatterjee, B.
author_facet	Ali, E. M. H. Mahmood, S. Sengupta, P. Doolaanea, A. A. Chatterjee, B.
author_sort	Ali, E. M. H.
title	Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation
title_short	Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation
title_full	Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation
title_fullStr	Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation
title_full_unstemmed	Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation
title_sort	sunflower oil based nanoemulsion loaded into carbopol gel: semisolid state characterization and ex vivo skin permeation
publisher	Indian Pharmaceutical Assoc
publishDate	2023
url	http://eprints.um.edu.my/38478/
_version_	1817841936057237504
score	13.239536

Sunflower oil based nanoemulsion loaded into carbopol gel: Semisolid state characterization and ex vivo skin permeation

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