Hits-to-Lead Optimization of the Natural Compound 2,4,6-Trihydroxy-3-geranyl-acetophenone (tHGA) as a Potent LOX Inhibitor: Synthesis, Structure-Activity Relationship (SAR) Study, and Computational Assignment
A new series of 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) analogues were synthesized and evaluated for their lipoxygenase (LOX) inhibitory activity. Prenylated analogues 4a-g (half maximal inhibitory concentration (IC50) values ranging from 35 μM to 95 μM) did not exhibit better inhibitory acti...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , |
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| التنسيق: | مقال |
| منشور في: |
MDPI
2018
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://eprints.um.edu.my/21149/ https://doi.org/10.3390/molecules23102509 |
| الوسوم: |
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