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Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid

Indomethacin is an acidic non-steroidal anti-inflammatory agent that used mainly for the relief of pain and severe inflammation in the treatment of rheumatic disease and similar disorders. Indomethacin is a poorly water-insoluble drug that leads to low absorption and bioavailability. The solution st...

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Main Author: Ismail @ Abdul Rashid, Norhafiza
Format: Thesis
Language:English
Published: 2013
Subjects:
Drugs and their actions
Pharmacopoeias
Online Access:https://ir.uitm.edu.my/id/eprint/110378/1/110378.PDF
https://ir.uitm.edu.my/id/eprint/110378/
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spelling my.uitm.ir.1103782025-02-14T11:55:25Z https://ir.uitm.edu.my/id/eprint/110378/ Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid Ismail @ Abdul Rashid, Norhafiza Drugs and their actions Pharmacopoeias Indomethacin is an acidic non-steroidal anti-inflammatory agent that used mainly for the relief of pain and severe inflammation in the treatment of rheumatic disease and similar disorders. Indomethacin is a poorly water-insoluble drug that leads to low absorption and bioavailability. The solution state characterization of polyvinyl pyrrolidone (PVP) wrapped was studied by using saturation solubility, drug content assay and dissolution efficiency. The standard plot was calibrated after obtained R2 = 0.9992. From the experiment, polyvinyl pyrrolidone wrapped indomethacin samples D (PVP-IDM-D) was showed maximum saturation solubility, 21.5 fold while the minimum saturation solubility is polyvinyl pyrrolidone wrapped indomethacin samples A (PVP-IDM-A), 8.63 fold. From the drug content assay, PVP-IDM-D showed 13.64% drug presence as compared to pure IDM with 96.94%. The dissolution study revealed a good result with 97.38% drug dissolved for PVP-IDM-D compared to 5.19% for pure IDM. In this study the results of the saturation solubility study and the dissolution study are complimenting each other. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110378/1/110378.PDF Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs and their actions
Pharmacopoeias
spellingShingle Drugs and their actions
Pharmacopoeias
Ismail @ Abdul Rashid, Norhafiza
Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid
description Indomethacin is an acidic non-steroidal anti-inflammatory agent that used mainly for the relief of pain and severe inflammation in the treatment of rheumatic disease and similar disorders. Indomethacin is a poorly water-insoluble drug that leads to low absorption and bioavailability. The solution state characterization of polyvinyl pyrrolidone (PVP) wrapped was studied by using saturation solubility, drug content assay and dissolution efficiency. The standard plot was calibrated after obtained R2 = 0.9992. From the experiment, polyvinyl pyrrolidone wrapped indomethacin samples D (PVP-IDM-D) was showed maximum saturation solubility, 21.5 fold while the minimum saturation solubility is polyvinyl pyrrolidone wrapped indomethacin samples A (PVP-IDM-A), 8.63 fold. From the drug content assay, PVP-IDM-D showed 13.64% drug presence as compared to pure IDM with 96.94%. The dissolution study revealed a good result with 97.38% drug dissolved for PVP-IDM-D compared to 5.19% for pure IDM. In this study the results of the saturation solubility study and the dissolution study are complimenting each other.
format Thesis
author Ismail @ Abdul Rashid, Norhafiza
author_facet Ismail @ Abdul Rashid, Norhafiza
author_sort Ismail @ Abdul Rashid, Norhafiza
title Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid
title_short Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid
title_full Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid
title_fullStr Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid
title_full_unstemmed Solution state characterization of polyvinyl pyrrolidone (PVP) wrapped indomethacin / Norhafiza Ismail @ Abdul Rashid
title_sort solution state characterization of polyvinyl pyrrolidone (pvp) wrapped indomethacin / norhafiza ismail @ abdul rashid
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110378/1/110378.PDF
https://ir.uitm.edu.my/id/eprint/110378/
_version_ 1825165184454361088
score 13.239859

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