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Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan

Self nanoemulsifying drug delivery system (SN EDDS) is a mixture of concentration of oils, surfactant and co-surfactant to dissolve the poorly soluble drugs (Curcumin). In this study, isopropyl myristate was used as the oil phase, Cremophore RH40 and polyethylene glycol as the surfactant and co-surf...

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Main Author: Sofwan, Nurul Jannah
Format: Thesis
Language:English
Published: 2013
Subjects:
Drugs and their actions
Pharmacopoeias
Online Access:https://ir.uitm.edu.my/id/eprint/110247/1/110247.PDF
https://ir.uitm.edu.my/id/eprint/110247/
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spelling my.uitm.ir.1102472025-02-16T08:20:50Z https://ir.uitm.edu.my/id/eprint/110247/ Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan Sofwan, Nurul Jannah Drugs and their actions Pharmacopoeias Self nanoemulsifying drug delivery system (SN EDDS) is a mixture of concentration of oils, surfactant and co-surfactant to dissolve the poorly soluble drugs (Curcumin). In this study, isopropyl myristate was used as the oil phase, Cremophore RH40 and polyethylene glycol as the surfactant and co-surfactant respectively. The mixture of isopropyl myristate, Cremophore RH40 and polyethylene glycol were allowed to self­ emulsify under gentle agitation. Next, the particle size was measured using Laser diffraction Malvern Mastersizer 2000MU and Malvern Zetasizer Nano ZS. The outcome shows that the ratio of oil, surfactant, and co-surfactant give a large influence to the particle size of the nanoemulsion. Finally, the composition of Cremophore RH40 29%, polyethylene glycol 12% and isopropyl myristate 59% has given the size of 200.1 ± 0.03055 which is the most stable and favovorable characteristics of all formulations. The Transmission Electon Microscope (TEM) was used to check the morphology of Curcumin particles. It could be seen that the micelles formed were irregular spherical in shape and the analysis of TEM images reveals that each globule is surrounded by a thick layer that reduces the interfacial energy, and leads to the formation of barrier to coalescence. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/110247/1/110247.PDF Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs and their actions
Pharmacopoeias
spellingShingle Drugs and their actions
Pharmacopoeias
Sofwan, Nurul Jannah
Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan
description Self nanoemulsifying drug delivery system (SN EDDS) is a mixture of concentration of oils, surfactant and co-surfactant to dissolve the poorly soluble drugs (Curcumin). In this study, isopropyl myristate was used as the oil phase, Cremophore RH40 and polyethylene glycol as the surfactant and co-surfactant respectively. The mixture of isopropyl myristate, Cremophore RH40 and polyethylene glycol were allowed to self­ emulsify under gentle agitation. Next, the particle size was measured using Laser diffraction Malvern Mastersizer 2000MU and Malvern Zetasizer Nano ZS. The outcome shows that the ratio of oil, surfactant, and co-surfactant give a large influence to the particle size of the nanoemulsion. Finally, the composition of Cremophore RH40 29%, polyethylene glycol 12% and isopropyl myristate 59% has given the size of 200.1 ± 0.03055 which is the most stable and favovorable characteristics of all formulations. The Transmission Electon Microscope (TEM) was used to check the morphology of Curcumin particles. It could be seen that the micelles formed were irregular spherical in shape and the analysis of TEM images reveals that each globule is surrounded by a thick layer that reduces the interfacial energy, and leads to the formation of barrier to coalescence.
format Thesis
author Sofwan, Nurul Jannah
author_facet Sofwan, Nurul Jannah
author_sort Sofwan, Nurul Jannah
title Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan
title_short Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan
title_full Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan
title_fullStr Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan
title_full_unstemmed Self-nanoemulsifying drug delivery systems (SNEDDS) of curcumin / Nurul Jannah Sofwan
title_sort self-nanoemulsifying drug delivery systems (snedds) of curcumin / nurul jannah sofwan
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/110247/1/110247.PDF
https://ir.uitm.edu.my/id/eprint/110247/
_version_ 1825165167605841920
score 13.239859

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