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Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun

Most of the liquid formulations are prepared in concentrations that are not suitable for administration to children. They have difficulty in swallowing drugs in solid dosage form such as tablets and capsules. To overcome this problem, drug suspensions are prepared extemporaneously by pharmacists by...

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Main Author: Harun, Nurul Dyana
Format: Thesis
Language:English
Published: 2013
Subjects:
Drugs and their actions
Pharmacopoeias
Online Access:https://ir.uitm.edu.my/id/eprint/109311/1/109311.PDF
https://ir.uitm.edu.my/id/eprint/109311/
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spelling my.uitm.ir.1093112025-02-18T18:04:47Z https://ir.uitm.edu.my/id/eprint/109311/ Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun Harun, Nurul Dyana Drugs and their actions Pharmacopoeias Most of the liquid formulations are prepared in concentrations that are not suitable for administration to children. They have difficulty in swallowing drugs in solid dosage form such as tablets and capsules. To overcome this problem, drug suspensions are prepared extemporaneously by pharmacists by reformulating the drug from the solid tablet dosage form to the suitable desirable dosage for pediatrics. Captopril is one of the common extemporaneously preparation prepared for treatment of children with heart failure. The aim of this study is to identify the stability of captopril syrup 1 mg/ml prepared by Hospital Sungai Buloh and to quantify the captopril syrup 1 mg/ml using HPLC. The HPLC system with UV detector with 220 nm wavelength was chosen. The samples were analyzed at day7, 14 and 21. The formulation found to be stable at 21 days at room temperature. The captopril syrup concentration was decreased by 12% of the initial concentration after 7days. 2013 Thesis NonPeerReviewed text en https://ir.uitm.edu.my/id/eprint/109311/1/109311.PDF Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun. (2013) Degree thesis, thesis, Universiti Teknologi MARA (Kampus Puncak Alam).
institution Universiti Teknologi Mara
building Tun Abdul Razak Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Mara
content_source UiTM Institutional Repository
url_provider http://ir.uitm.edu.my/
language English
topic Drugs and their actions
Pharmacopoeias
spellingShingle Drugs and their actions
Pharmacopoeias
Harun, Nurul Dyana
Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun
description Most of the liquid formulations are prepared in concentrations that are not suitable for administration to children. They have difficulty in swallowing drugs in solid dosage form such as tablets and capsules. To overcome this problem, drug suspensions are prepared extemporaneously by pharmacists by reformulating the drug from the solid tablet dosage form to the suitable desirable dosage for pediatrics. Captopril is one of the common extemporaneously preparation prepared for treatment of children with heart failure. The aim of this study is to identify the stability of captopril syrup 1 mg/ml prepared by Hospital Sungai Buloh and to quantify the captopril syrup 1 mg/ml using HPLC. The HPLC system with UV detector with 220 nm wavelength was chosen. The samples were analyzed at day7, 14 and 21. The formulation found to be stable at 21 days at room temperature. The captopril syrup concentration was decreased by 12% of the initial concentration after 7days.
format Thesis
author Harun, Nurul Dyana
author_facet Harun, Nurul Dyana
author_sort Harun, Nurul Dyana
title Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun
title_short Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun
title_full Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun
title_fullStr Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun
title_full_unstemmed Quantification study of captopril extemporaneously prepared by Hospital Sungai Buloh / Nurul Dyana Harun
title_sort quantification study of captopril extemporaneously prepared by hospital sungai buloh / nurul dyana harun
publishDate 2013
url https://ir.uitm.edu.my/id/eprint/109311/1/109311.PDF
https://ir.uitm.edu.my/id/eprint/109311/
_version_ 1825165111278436352
score 13.239859

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